Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases

المؤلف

Pawitan, Jeanne Adiwinata

المصدر

Stem Cells International

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-02-12

دولة النشر

مصر

عدد الصفحات

7

الملخص EN

In genetic diseases, where the cells are already damaged, the damaged cells can be replaced by new normal cells, which can be differentiated from iPSC.

To avoid immune rejection, iPSC from the patient’s own cell can be developed.

However, iPSC from the patients’s cell harbors the same genetic aberration.

Therefore, before differentiating the iPSCs into required cells, genetic repair should be done.

This review discusses the various technologies to repair the genetic aberration in patient-derived iPSC, or to prevent the genetic aberration to cause further damage in the iPSC-derived cells, such as Zn finger and TALE nuclease genetic editing, RNA interference technology, exon skipping, and gene transfer method.

In addition, the challenges in using the iPSC and the strategies to manage the hurdles are addressed.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Pawitan, Jeanne Adiwinata. 2012. Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases. Stem Cells International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1003030

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Pawitan, Jeanne Adiwinata. Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases. Stem Cells International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1003030

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Pawitan, Jeanne Adiwinata. Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1003030

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1003030