Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study
المؤلفون المشاركون
Venkataramana, N. K.
Pal, Rakhi
Rao, Shailesh A. V.
Naik, Arun L.
Jan, Majahar
Nair, Rahul
Sanjeev, C. C.
Kamble, Ravindra B.
Murthy, D. P.
Chaitanya, Krishna
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-13
دولة النشر
مصر
عدد الصفحات
12
الملخص EN
The progress of PD and its related disorders cannot be prevented with the medications available.
In this study, we recruited 8 PD and 4 PD plus patients between 5 to 15 years after diagnosis.
All patients received BM-MSCs bilaterally into the SVZ and were followed up for 12 months.
PD patients after therapy reported a mean improvement of 17.92% during “on” and 31.21% during “off” period on the UPDRS scoring system.
None of the patients increased their medication during the follow-up period.
Subjectively, the patients reported clarity in speech, reduction in tremors, rigidity, and freezing attacks.
The results correlated with the duration of the disease.
Those patients transplanted in the early stages of the disease (less than 5 years) showed more improvement and no further disease progression than the later stages (11–15 years).
However, the PD plus patients did not show any change in their clinical status after stem cell transplantation.
This study demonstrates the safety of adult allogenic human BM-MSCs transplanted into the SVZ of the brain and its efficacy in early-stage PD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Venkataramana, N. K.& Pal, Rakhi& Rao, Shailesh A. V.& Naik, Arun L.& Jan, Majahar& Nair, Rahul…[et al.]. 2012. Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study. Stem Cells International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1003131
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Venkataramana, N. K.…[et al.]. Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study. Stem Cells International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1003131
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Venkataramana, N. K.& Pal, Rakhi& Rao, Shailesh A. V.& Naik, Arun L.& Jan, Majahar& Nair, Rahul…[et al.]. Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1003131
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003131
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر