IL-17 in the Rheumatologist’s Line of Sight

الملخص EN

Over the past decades, the identification of several new cytokines, including interleukin (IL)-17 and IL-23, and of new T helper cell subsets, including Th17 cells, has changed the vision of immunological processes.

The IL-17/Th17 pathway plays a critical role during the development of inflammation and autoimmunity, and targeting this pathway has become an attractive strategy for a number of diseases.

This review aims to describe the effects of IL-17 in the joint and its roles in the development of autoimmune and inflammatory arthritis.

Furthermore, biotherapies targeting directly or indirectly IL-17 in inflammatory rheumatisms will be developed.