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Regulatory Interactions between Androgens, Hoxb5, and TGFβ Signaling in Murine Lung Development
المؤلفون المشاركون
Volpe, MaryAnn V.
Ramadurai, Sujatha M.
Mujahid, Sana
Vong, Thanhxuan
Brandao, Marcia
Wang, Karen T.
Pham, Lucia D.
Nielsen, Heber C.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Androgens enhance airway branching but delay alveolar maturation contributing to increased respiratory morbidity in prematurely born male infants.
Hoxb5 protein positively regulates airway branching in developing lung.
In other organs, androgen regulation intersects with Hox proteins and TGFβ-SMAD signaling, but these interactions have not been studied in the lung.
We hypothesized that androgen alteration of airway branching early in lung development requires Hoxb5 expression and that these androgen-Hoxb5 interactions occur partially through regional changes in TGFβ signaling.
To evaluate acute effects of androgen and TGFβ on Hoxb5, E11 whole fetal mouse lungs were cultured with dihydrotestosterone (DHT) with/without Hoxb5 siRNA or TGFβ inhibitory antibody.
Chronic in utero DHT exposure was accomplished by exposing pregnant mice to DHT (subcutaneous pellet) from E11 to E18.
DHT’s ability to enhance airway branching and alter phosphorylated SMAD2 cellular localization was partially dependent on Hoxb5.
Hoxb5 inhibition also changed the cellular distribution of SMAD7 protein.
Chronic in utero DHT increased Hoxb5 and altered SMAD7 mesenchymal localization.
TGFβ inhibition enhanced airway branching, and Hoxb5 protein cellular localization was more diffuse.
We conclude that DHT controls lung airway development partially through modulation of Hoxb5 protein expression and that this level of regulation involves interactions with TGFβ signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Volpe, MaryAnn V.& Ramadurai, Sujatha M.& Mujahid, Sana& Vong, Thanhxuan& Brandao, Marcia& Wang, Karen T.…[et al.]. 2013. Regulatory Interactions between Androgens, Hoxb5, and TGFβ Signaling in Murine Lung Development. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Volpe, MaryAnn V.…[et al.]. Regulatory Interactions between Androgens, Hoxb5, and TGFβ Signaling in Murine Lung Development. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Volpe, MaryAnn V.& Ramadurai, Sujatha M.& Mujahid, Sana& Vong, Thanhxuan& Brandao, Marcia& Wang, Karen T.…[et al.]. Regulatory Interactions between Androgens, Hoxb5, and TGFβ Signaling in Murine Lung Development. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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