Whole Blood Platelet Aggregation and Release Reaction Testing in Uremic Patients

المؤلفون المشاركون

Zeck, Jay
Schallheim, Jason
Lew, Susie Q.
DePalma, Louis

المصدر

BioMed Research International

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-06-26

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Platelet function analysis utilizing platelet-rich plasma and optical density based aggregometry fails to identify patients at risk for uremia associated complications.

Methods.

We employed whole blood platelet aggregation analysis based on impedance as well as determination of ATP release from platelet granules detected by a chemiluminescence method.

Ten chronic kidney disease (CKD) stage 4 or 5 predialysis patients underwent platelet evaluation.

Our study aims to evaluate this platform in this patient population to determine if abnormalities could be detected.

Results.

Analysis revealed normal aggregation and ATP release to collagen, ADP, and high-dose ristocetin.

ATP release had a low response to arachidonic acid (0.37 ± 0.26 nmoles, reference range: 0.6–1.4 nmoles).

Platelet aggregation to low-dose ristocetin revealed an exaggerated response (20.9 ± 18.7 ohms, reference range: 0–5 ohms).

Conclusions.

Whole blood platelet analysis detected platelet dysfunction which may be associated with bleeding and thrombotic risks in uremia.

Diminished ATP release to arachidonic acid (an aspirin-like defect) in uremic patients may result in platelet associated bleeding.

An increased aggregation response to low-dose ristocetin (a type IIb von Willebrand disease-like defect) is associated with thrombus formation.

This platelet hyperreactivity may be associated with a thrombotic diathesis as seen in some uremic patients.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zeck, Jay& Schallheim, Jason& Lew, Susie Q.& DePalma, Louis. 2013. Whole Blood Platelet Aggregation and Release Reaction Testing in Uremic Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004431

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zeck, Jay…[et al.]. Whole Blood Platelet Aggregation and Release Reaction Testing in Uremic Patients. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004431

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zeck, Jay& Schallheim, Jason& Lew, Susie Q.& DePalma, Louis. Whole Blood Platelet Aggregation and Release Reaction Testing in Uremic Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004431

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1004431