An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction
المؤلفون المشاركون
Chaudhary, Amit Kumar
Dhakal, Dipesh
Sohng, Jae Kyung
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-02
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Microorganisms produce a range of chemical substances representing a vast diversity of fascinating molecular architectures not available in any other system.
Among them, Streptomyces are frequently used to produce useful enzymes and a wide variety of secondary metabolites with potential biological activities.
Streptomyces are preferred over other microorganisms for producing more than half of the clinically useful naturally originating pharmaceuticals.
However, these compounds are usually produced in very low amounts (or not at all) under typical laboratory conditions.
Despite the superiority of Streptomyces, they still lack well documented genetic information and a large number of in-depth molecular biological tools for strain improvement.
Previous attempts to produce high yielding strains required selection of the genetic material through classical mutagenesis for commercial production of secondary metabolites, optimizing culture conditions, and random selection.
However, a profound effect on the strategy for strain development has occurred with the recent advancement of whole-genome sequencing, systems biology, and genetic engineering.
In this review, we demonstrate a few of the major issues related to the potential of “-omics” technology (genomics, transcriptomics, proteomics, and metabolomics) for improving streptomycetes as an intelligent chemical factory for enhancing the production of useful bioactive compounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chaudhary, Amit Kumar& Dhakal, Dipesh& Sohng, Jae Kyung. 2013. An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1005536
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chaudhary, Amit Kumar…[et al.]. An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1005536
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chaudhary, Amit Kumar& Dhakal, Dipesh& Sohng, Jae Kyung. An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1005536
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005536
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر