KIF6 719Arg Carrier Status Association with Homocysteine and C-Reactive Protein in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Patients
المؤلفون المشاركون
Sabbagh, Marwan N.
Patel, Amar
Malek-Ahmadi, Michael
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Recent research has demonstrated associations between statin use, KIF6 719Arg carrier status, and cholesterol levels and amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) patients.
The association between 719Arg carrier status with homocysteine (tHcy) and c-reactive protein (CRP) levels in aMCI and AD has not been previously investigated.
Data from 175 aMCI and AD patients were used for the analysis.
719Arg carriers had significantly lower levels of tHcy than noncarriers (P=0.02).
No significant difference in CRP levels between 719Arg carriers and noncarriers was present (P=0.37).
Logistic regression yielded no significant effect for 719Arg status on CRP [OR = 1.79 (0.85, 3.83), P=0.13] but did demonstrate a significant effect for tHcy [OR = 0.44 (0.23, 0.83), P=0.01] after adjusting for ApoE ε4 carrier status, age, gender, and statin use.
This study is the first to explore the relationship between KIF6 719Arg carrier status with tHcy and CRP levels.
719Arg carriers were more likely to have normal tHcy levels after adjusting for ApoE ε4 status, age, gender, and statin use.
These results suggest that the KIF6 gene might influence cardiovascular pathways associated with AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malek-Ahmadi, Michael& Patel, Amar& Sabbagh, Marwan N.. 2013. KIF6 719Arg Carrier Status Association with Homocysteine and C-Reactive Protein in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Patients. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005909
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malek-Ahmadi, Michael…[et al.]. KIF6 719Arg Carrier Status Association with Homocysteine and C-Reactive Protein in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Patients. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1005909
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malek-Ahmadi, Michael& Patel, Amar& Sabbagh, Marwan N.. KIF6 719Arg Carrier Status Association with Homocysteine and C-Reactive Protein in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Patients. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1005909
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005909
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر