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Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction
المؤلفون المشاركون
Masters, Colin L.
Cherny, Robert A.
McLean, Catriona
Hare, Dominic J.
Fowler, Christopher J.
Roberts, Blaine R.
Rembach, Alan
Bush, Ashley I.
Lind, Monica
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is the leading cause of dementia and represents a significant burden on the global economy and society.
The role of transition metals, in particular copper (Cu), in AD has become of significant interest due to the dyshomeostasis of these essential elements, which can impart profound effects on cell viability and neuronal function.
We tested the hypothesis that there is a systemic perturbation in Cu compartmentalization in AD, within the brain as well as in the periphery, specifically within erythrocytes.
Our results showed that the previously reported decrease in Cu within the human frontal cortex was confined to the soluble (P<0.05) and total homogenate (P<0.05) fractions.
No differences were observed in Cu concentration in erythrocytes.
Our data indicate that there is a brain specific alteration in Cu levels in AD localized to the soluble extracted material, which is not reflected in erythrocytes.
Further studies using metalloproteomics approaches will be able to elucidate the metabolic mechanism(s) that results in the decreased brain Cu levels during the progression of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rembach, Alan& Hare, Dominic J.& Lind, Monica& Fowler, Christopher J.& Cherny, Robert A.& McLean, Catriona…[et al.]. 2013. Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005915
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rembach, Alan…[et al.]. Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1005915
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rembach, Alan& Hare, Dominic J.& Lind, Monica& Fowler, Christopher J.& Cherny, Robert A.& McLean, Catriona…[et al.]. Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1005915
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1005915
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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