Detection of AntiphosphatidylserineProthrombin Antibodies and Their Potential Diagnostic Value
المؤلفون المشاركون
Kveder, Tanja
Ambrožič, Aleš
Čučnik, Saša
Žigon, Polona
Sodin-Semrl, Snezna
Rozman, Blaž
Božič, Borut
المصدر
Journal of Immunology Research
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Antiprothrombin antibodies, measured with phosphatidylserine/prothrombin complex (aPS/PT) ELISA, have been reported to be associated with antiphospholipid syndrome (APS).
They are currently being evaluated as a potential classification criterion for this autoimmune disease, characterized by thromboses and obstetric complications.
Given the present lack of clinically useful tests for the accurate diagnosis of APS, we aimed to evaluate in-house and commercial assays for determination of aPS/PT as a potential serological marker for APS.
We screened 156 patients with systemic autoimmune diseases for antibodies against PS/PT, β2-glycoprotein I, cardiolipin and for lupus anticoagulant activity.
We demonstrated a high degree of concordance between the concentrations of aPS/PT measured with the in-house and commercial assays.
Both assays performed comparably relating to the clinical manifestations of APS, such as arterial and venous thromboses and obstetric complications.
IgG aPS/PT represented the strongest independent risk factor for the presence of obstetric complications, among all tested aPL.
Both IgG and IgM aPS/PT were associated with venous thrombosis, but not with arterial thrombosis.
Most importantly, the association between the presence of IgG/IgM aPS/PT and lupus anticoagulant activity was highly significant.
Taken together, aPS/PT antibodies detected with the in-house or commercial ELISA represent a promising serological marker for APS and its subsets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Žigon, Polona& Čučnik, Saša& Ambrožič, Aleš& Kveder, Tanja& Sodin-Semrl, Snezna& Rozman, Blaž…[et al.]. 2013. Detection of AntiphosphatidylserineProthrombin Antibodies and Their Potential Diagnostic Value. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006895
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Žigon, Polona…[et al.]. Detection of AntiphosphatidylserineProthrombin Antibodies and Their Potential Diagnostic Value. Journal of Immunology Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1006895
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Žigon, Polona& Čučnik, Saša& Ambrožič, Aleš& Kveder, Tanja& Sodin-Semrl, Snezna& Rozman, Blaž…[et al.]. Detection of AntiphosphatidylserineProthrombin Antibodies and Their Potential Diagnostic Value. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006895
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1006895
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر