Inhibition of Brain Swelling after Ischemia-Reperfusion by β-Adrenergic Antagonists: Correlation with Increased K+ and Decreased Ca2+ Concentrations in Extracellular Fluid
المؤلفون المشاركون
Song, Dan
Xu, Junnan
Du, Ting
Yan, Enzhi
Hertz, Leif
Walz, Wolfgang
Peng, Liang
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Infarct size and brain edema following ischemia/reperfusion are reduced by inhibitors of the Na+, K+, 2Cl−, and water cotransporter NKCC1 and by β 1-adrenoceptor antagonists.
NKCC1 is a secondary active transporter, mainly localized in astrocytes, driven by transmembrane Na+/K+ gradients generated by the Na+,K+-ATPase.
The astrocytic Na+,K+-ATPase is stimulated by small increases in extracellular K+ concentration and by the β-adrenergic agonist isoproterenol.
Larger K+ increases, as occurring during ischemia, also stimulate NKCC1, creating cell swelling.
This study showed no edema after 3 hr medial cerebral artery occlusion but pronounced edema after 8 hr reperfusion.
The edema was abolished by inhibitors of specifically β 1-adrenergic pathways, indicating failure of K+-mediated, but not β 1-adrenoceptor-mediated, stimulation of Na+,K+-ATPase/NKCC1 transport during reoxygenation.
Ninety percent reduction of extracellular Ca2+ concentration occurs in ischemia.
Ca2+ omission abolished K+ uptake in normoxic cultures of astrocytes after addition of 5 mM KCl.
A large decrease in ouabain potency on K+ uptake in cultured astrocytes was also demonstrated in Ca2+-depleted media, and endogenous ouabains are needed for astrocytic K+ uptake.
Thus, among the ionic changes induced by ischemia, the decrease in extracellular Ca2+ causes failure of the high-K+-stimulated Na+,K+-ATPase/NKCC1 ion/water uptake, making β 1-adrenergic activation the only stimulus and its inhibition effective against edema.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Dan& Xu, Junnan& Du, Ting& Yan, Enzhi& Hertz, Leif& Walz, Wolfgang…[et al.]. 2014. Inhibition of Brain Swelling after Ischemia-Reperfusion by β-Adrenergic Antagonists: Correlation with Increased K+ and Decreased Ca2+ Concentrations in Extracellular Fluid. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016618
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Dan…[et al.]. Inhibition of Brain Swelling after Ischemia-Reperfusion by β-Adrenergic Antagonists: Correlation with Increased K+ and Decreased Ca2+ Concentrations in Extracellular Fluid. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016618
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Dan& Xu, Junnan& Du, Ting& Yan, Enzhi& Hertz, Leif& Walz, Wolfgang…[et al.]. Inhibition of Brain Swelling after Ischemia-Reperfusion by β-Adrenergic Antagonists: Correlation with Increased K+ and Decreased Ca2+ Concentrations in Extracellular Fluid. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016618
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1016618
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر