Genetic Polymorphisms Involved in Folate Metabolism and Maternal Risk for Down Syndrome: A Meta-Analysis
المؤلفون المشاركون
Balduino Victorino, Daniella
de Godoy, Moacir Fernandes
Goloni-Bertollo, Eny Maria
Pavarino, Érika Cristina
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Inconclusive results of the association between genetic polymorphisms involved in folate metabolism and maternal risk for Down syndrome (DS) have been reported.
Therefore, this meta-analysis was conducted.
We searched electronic databases through May, 2014, for eligible studies.
Pooled odds ratios with 95% confidence intervals were used to assess the strength of the association, which was estimated by fixed or random effects models.
Heterogeneity among studies was evaluated using Q-test and I 2 statistic.
Subgroup and sensitivity analyses were also conducted.
Publication bias was estimated using Begg’s and Egger’s tests.
A total of 17 case-controls studies were included.
There was evidence for an association between the MTRR c.66A>G (rs1801394) polymorphism and maternal risk for DS.
In the subgroup analysis, increased maternal risk for DS was found in Caucasians.
Additionally, the polymorphic heterozygote MTHFD1 1958GA genotype was associated significantly with maternal risk for DS, when we limit the analysis by studies conformed to Hardy-Weinberg equilibrium.
Finally, considering MTR c.2756A>G (rs1805087), TC2 c.776C>G (rs1801198), and CBS c.844ins68, no significant associations have been found, neither in the overall analyses nor in the stratified analyses by ethnicity.
In conclusion, our meta-analysis suggested that the MTRR c.66A>G (rs1801394) polymorphism and MTHFD1 c.1958G>A (rs2236225) were associated with increased maternal risk for DS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Balduino Victorino, Daniella& de Godoy, Moacir Fernandes& Goloni-Bertollo, Eny Maria& Pavarino, Érika Cristina. 2014. Genetic Polymorphisms Involved in Folate Metabolism and Maternal Risk for Down Syndrome: A Meta-Analysis. Disease Markers،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Balduino Victorino, Daniella…[et al.]. Genetic Polymorphisms Involved in Folate Metabolism and Maternal Risk for Down Syndrome: A Meta-Analysis. Disease Markers No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1018011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Balduino Victorino, Daniella& de Godoy, Moacir Fernandes& Goloni-Bertollo, Eny Maria& Pavarino, Érika Cristina. Genetic Polymorphisms Involved in Folate Metabolism and Maternal Risk for Down Syndrome: A Meta-Analysis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر