Salidroside Reduces Cell Mobility via NF- κB and MAPK Signaling in LPS-Induced BV2 Microglial Cells
المؤلفون المشاركون
Hu, Haixia
Li, Zuanfang
Zhu, Xiaoqin
Lin, Ruhui
Chen, Lidian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The unregulated activation of microglia following stroke results in the production of toxic factors that propagate secondary neuronal injury.
Salidroside has been shown to exhibit protective effects against neuronal death induced by different insults.
However, the molecular mechanisms responsible for the anti-inflammatory activity of salidroside have not been elucidated clearly in microglia.
In the present study, we investigated the molecular mechanism underlying inhibiting LPS-stimulated BV2 microglial cell mobility of salidroside.
The protective effect of salidroside was investigated in microglial BV2 cell, subjected to stretch injury.
Moreover, transwell migration assay demonstrated that salidroside significantly reduced cell motility.
Our results also indicated that salidroside suppressed LPS-induced chemokines production in a dose-dependent manner, without causing cytotoxicity in BV2 microglial cells.
Moreover, salidroside suppressed LPS-induced activation of nuclear factor kappa B (NF-κB) by blocking degradation of IκBα and phosphorylation of MAPK (p38, JNK, ERK1/2), which resulted in inhibition of chemokine expression.
These results suggest that salidroside possesses a potent suppressive effect on cell migration of BV2 microglia and this compound may offer substantial therapeutic potential for treatment of ischemic strokes that are accompanied by microglial activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Haixia& Li, Zuanfang& Zhu, Xiaoqin& Lin, Ruhui& Chen, Lidian. 2014. Salidroside Reduces Cell Mobility via NF- κB and MAPK Signaling in LPS-Induced BV2 Microglial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018425
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Haixia…[et al.]. Salidroside Reduces Cell Mobility via NF- κB and MAPK Signaling in LPS-Induced BV2 Microglial Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018425
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Haixia& Li, Zuanfang& Zhu, Xiaoqin& Lin, Ruhui& Chen, Lidian. Salidroside Reduces Cell Mobility via NF- κB and MAPK Signaling in LPS-Induced BV2 Microglial Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018425
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018425
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر