New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid- β -Induced Progression of Tau Phosphorylation and Axonal Atrophy
المؤلفون المشاركون
Tohda, Chihiro
Watari, Hidetoshi
Shimada, Yutaka
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aims.
We previously reported that kamikihito (KKT), a traditional Japanese medicine, improved memory impairment and reversed the degeneration of axons in the 5XFAD mouse model of Alzheimer’s disease (AD).
However, the mechanism underlying the effects of KKT remained unknown.
The aim of the present study was to investigate the mechanism by which KKT reverses the progression of axonal degeneration.
Methods.
Primary cultured cortical neurons were treated with amyloid beta (Aβ) fragment comprising amino acid residues (25–35) (10 μM) in an in vitro AD model.
KKT (10 μg/mL) was administered to the cells before or after Aβ treatment.
The effects of KKT on Aβ-induced tau phosphorylation, axonal atrophy, and protein phosphatase 2A (PP2A) activity were investigated.
We also performed an in vivo assay in which KKT (500 mg/kg/day) was administered to 5XFAD mice once a day for 15 days.
Cerebral cortex homogenates were used to measure PP2A activity.
Results.
KKT improved Aβ-induced tau phosphorylation and axonal atrophy after they had already progressed.
In addition, KKT increased PP2A activity in vitro and in vivo.
Conclusions.
KKT reversed the progression of Aβ-induced axonal degeneration.
KKT reversed axonal degeneration at least in part through its role as an exogenous PP2A stimulator.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Watari, Hidetoshi& Shimada, Yutaka& Tohda, Chihiro. 2014. New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid- β -Induced Progression of Tau Phosphorylation and Axonal Atrophy. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Watari, Hidetoshi…[et al.]. New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid- β -Induced Progression of Tau Phosphorylation and Axonal Atrophy. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Watari, Hidetoshi& Shimada, Yutaka& Tohda, Chihiro. New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid- β -Induced Progression of Tau Phosphorylation and Axonal Atrophy. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1018919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر