Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation

المؤلفون المشاركون

Shuid, Ahmad Nazrun
Mohamad, Sharlina
Abdullah, Shahrum
Mokhtar, Sabarul Afian
Soelaiman, Ima Nirwana

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-07-05

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

This study investigated the effects of α-tocopherol and palm oil tocotrienol supplementations on bone fracture healing in postmenopausal osteoporosis rats.

32 female Sprague-Dawley rats were divided into four groups.

The first group was sham operated (SO), while the others were ovariectomised.

After 2 months, the right femora were fractured under anesthesia and fixed with K-wire.

The SO and ovariectomised-control rats (OVXC) were given olive oil (vehicle), while both the alpha-tocopherol (ATF) and tocotrienol-enriched fraction (TEF) groups were given alpha-tocopherol and tocotrienol-enriched fraction, respectively, at the dose of 60 mg/kg via oral gavages 6 days per week for 8 weeks.

The rats were then euthanized and the femora dissected out for bone biomechanical testing to assess their strength.

The callous of the TEF group had significantly higher stress parameter than the SO and OVXC groups.

Only the SO group showed significantly higher strain parameter compared to the other treatment groups.

The load parameter of the OVXC and ATF groups was significantly lower than the SO group.

There was no significant difference in the Young’s modulus between the groups.

In conclusion, tocotrienol is better than α-tocopherol in improving the biomechanical properties of the fracture callous in postmenopausal osteoporosis rat model.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Mohamad, Sharlina& Shuid, Ahmad Nazrun& Mokhtar, Sabarul Afian& Abdullah, Shahrum& Soelaiman, Ima Nirwana. 2012. Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028277

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Mohamad, Sharlina…[et al.]. Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028277

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Mohamad, Sharlina& Shuid, Ahmad Nazrun& Mokhtar, Sabarul Afian& Abdullah, Shahrum& Soelaiman, Ima Nirwana. Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028277

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1028277