The ent-15α-Acetoxykaur-16-en-19-oic Acid Relaxes Rat Artery Mesenteric Superior via Endothelium-Dependent and Endothelium-Independent Mechanisms
المؤلفون المشاركون
Ribeiro, Êurica Adélia Nogueira
Herculano, Edla de Azevedo
Costa, Cintia Danieli Ferreira da
Furtado, Fabiola Fialho
da-Cunha, Emídio Vasconcelos Leitão
Barbosa-Filho, José Maria
da Silva, Marcelo Sobral
Medeiros, Isac Almeida de
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The objective of the study was to investigate the mechanism of the relaxant activity of the ent-15α-acetoxykaur-16-en-19-oic acid (KA-acetoxy).
In rat mesenteric artery rings, KA-acetoxy induced a concentration-dependent relaxation in vessels precontracted with phenylephrine.
In the absence of endothelium, the vasorelaxation was significantly shifted to the right without reduction of the maximum effect.
Endothelium-dependent relaxation was significantly attenuated by pretreatment with L-NAME, an inhibitor of the NO-synthase (NOS), indomethacin, an inhibitor of the cyclooxygenase, L-NAME + indomethacin, atropine, a nonselective antagonist of the muscarinic receptors, ODQ, selective inhibitor of the guanylyl cyclase enzyme, or hydroxocobalamin, a nitric oxide scavenger.
The relaxation was completely reversed in the presence of L-NAME + 1 mM L-arginine or L-arginine, an NO precursor.
Diterpene-induced relaxation was not affected by TEA, a nonselective inhibitor of K+ channels.
The KA-acetoxy antagonized CaCl2-induced contractions in a concentration-dependent manner and also inhibited an 80 mM KCl-induced contraction.
The KA-acetoxy did not interfere with Ca2+ release from intracellular stores.
The vasorelaxant induced by KA-acetoxy seems to involve the inhibition of the Ca2+ influx and also, at least in part, by endothelial muscarinic receptors activation, NO and PGI2 release.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ribeiro, Êurica Adélia Nogueira& Herculano, Edla de Azevedo& Costa, Cintia Danieli Ferreira da& Furtado, Fabiola Fialho& da-Cunha, Emídio Vasconcelos Leitão& Barbosa-Filho, José Maria…[et al.]. 2012. The ent-15α-Acetoxykaur-16-en-19-oic Acid Relaxes Rat Artery Mesenteric Superior via Endothelium-Dependent and Endothelium-Independent Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028329
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ribeiro, Êurica Adélia Nogueira…[et al.]. The ent-15α-Acetoxykaur-16-en-19-oic Acid Relaxes Rat Artery Mesenteric Superior via Endothelium-Dependent and Endothelium-Independent Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028329
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ribeiro, Êurica Adélia Nogueira& Herculano, Edla de Azevedo& Costa, Cintia Danieli Ferreira da& Furtado, Fabiola Fialho& da-Cunha, Emídio Vasconcelos Leitão& Barbosa-Filho, José Maria…[et al.]. The ent-15α-Acetoxykaur-16-en-19-oic Acid Relaxes Rat Artery Mesenteric Superior via Endothelium-Dependent and Endothelium-Independent Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028329
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028329
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر