Cytotoxic and Antifungal Activities of 5-Hydroxyramulosin, a Compound Produced by an Endophytic Fungus Isolated from Cinnamomum mollisimum
المؤلفون المشاركون
Santiago, Carolina
Fitchett, Chris
Jalil, Juriyati
Santhanam, Jacinta
Munro, Murray H. G.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
An endophytic fungus isolated from the plant Cinnamomum mollissimum was investigated for the bioactivity of its metabolites.
The fungus, similar to a Phoma sp., was cultured in potato dextrose broth for two weeks, followed by extraction with ethyl acetate.
The crude extract obtained was fractionated by high-performance liquid chromatography.
Both crude extract and fractions were assayed for cytotoxicity against P388 murine leukemic cells and inhibition of bacterial and fungal pathogens.
The bioactive extract fraction was purified further and characterized by nuclear magnetic resonance, mass spectral and X-ray crystallography analysis.
A polyketide compound, 5-hydroxyramulosin, was identified as the constituent of the bioactive fungal extract fraction.
This compound inhibited the fungal pathogen Aspergillus niger (IC50 1.56 μg/mL) and was cytotoxic against murine leukemia cells (IC50 2.10 μg/mL).
5-Hydroxyramulosin was the major compound produced by the endophytic fungus.
This research suggests that fungal endophytes are a good source of bioactive metabolites which have potential applications in medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santiago, Carolina& Fitchett, Chris& Munro, Murray H. G.& Jalil, Juriyati& Santhanam, Jacinta. 2012. Cytotoxic and Antifungal Activities of 5-Hydroxyramulosin, a Compound Produced by an Endophytic Fungus Isolated from Cinnamomum mollisimum. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santiago, Carolina…[et al.]. Cytotoxic and Antifungal Activities of 5-Hydroxyramulosin, a Compound Produced by an Endophytic Fungus Isolated from Cinnamomum mollisimum. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1028470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santiago, Carolina& Fitchett, Chris& Munro, Murray H. G.& Jalil, Juriyati& Santhanam, Jacinta. Cytotoxic and Antifungal Activities of 5-Hydroxyramulosin, a Compound Produced by an Endophytic Fungus Isolated from Cinnamomum mollisimum. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر