Rats Born to Mothers Treated with Dexamethasone 15 cH Present Changes in Modulation of Inflammatory Process
المؤلفون المشاركون
Bonamin, Leoni Villano
de Moraes, Cristiane Landi
Sanches, Fernanda
Duran Filho, Claudemir
Martini, Lucienne C.
Sato, Cesar
Cardoso, Thayná Neves
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
As little information about the effect of ultra high dilutions of glucocorticoid in reproduction is available in the literature, pregnant female Wistar rats (N=12) were blindly subcutaneously treated during all gestational and lactation period with: dexamethasone 4 mg/kg diluted into dexamethasone 15 cH (mixed); or dexamethasone 4 mg/kg diluted in water; or dexamethasone 15 cH, or vehicle.
Parental generation had body weight, food and water consumption monitored.
The F1 generation was monitored regarding to newborn development.
No birth occurred in both groups treated with dexamethasone 4 mg/kg.
After 60 days from birth, 12 male F1 rats were randomly selected from each remaining group and inoculated subcutaneously with 1% carrageenan into the footpad, for evaluation of inflammatory performance.
Edema and histopathology of the footpad were evaluated, using specific staining methods, immunohistochemistry and digital histomorphometry.
Mothers treated with mixed dexamethasone presented reduced water consumption.
F1 rats born to dexamethasone 15 cH treated females presented significant increase in mast cell degranulation, decrease in monocyte percentage, increase in CD18+ PMN cells, and early expression of ED2 protein, in relation to control.
The results show that the exposure of parental generation to highly diluted dexamethasone interferes in inflammation modulation in the F1 generation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bonamin, Leoni Villano& de Moraes, Cristiane Landi& Sanches, Fernanda& Cardoso, Thayná Neves& Sato, Cesar& Duran Filho, Claudemir…[et al.]. 2012. Rats Born to Mothers Treated with Dexamethasone 15 cH Present Changes in Modulation of Inflammatory Process. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028497
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bonamin, Leoni Villano…[et al.]. Rats Born to Mothers Treated with Dexamethasone 15 cH Present Changes in Modulation of Inflammatory Process. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028497
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bonamin, Leoni Villano& de Moraes, Cristiane Landi& Sanches, Fernanda& Cardoso, Thayná Neves& Sato, Cesar& Duran Filho, Claudemir…[et al.]. Rats Born to Mothers Treated with Dexamethasone 15 cH Present Changes in Modulation of Inflammatory Process. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028497
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028497
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر