The Human Stratum Corneum Prevents Small Gold Nanoparticle Penetration and Their Potential Toxic Metabolic Consequences
المؤلفون المشاركون
Soyer, Hans Peter
Liu, David C.
Raphael, Anthony P.
Sundh, Daniel
Grice, Jeffrey E.
Roberts, Michael S.
Prow, Tarl W.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Nanoparticles are being used in multiple applications, ranging from biomedical and skin care products (e.g., sunscreen) through to industrial manufacturing processes (e.g., water purification).
The increase in exposure has led to multiple reports on nanoparticle penetration and toxicity.
However, the correlation between nanoparticle size and its penetration without physical/chemical enhancers through the skin is poorly understood—with studies instead focusing primarily on skin penetration under disrupted conditions.
In this paper, we investigate the penetration and metabolic effects of 10 nm, 30 nm, and 60 nm gold nanoparticles within viable excised human skin after 24-hour exposure using multiphoton tomograph-fluorescence lifetime imaging microscopy.
After 24 hour treatment with the 10, 30, and 60 nm gold nanoparticles, there was no significant penetration detected below the stratum corneum.
Furthermore, there were no changes in metabolic output (total NAD(P)H) in the viable epidermis posttreatment correlating with lack of penetration of nanoparticles.
These results are significant for estimating topical nanoparticle exposure in humans where other model systems may overestimate the exposure of nanoparticles to the viable epidermis.
Our data shows that viable human skin resists permeation of small nanoparticles in a size range that has been reported to penetrate deeply in other skin models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, David C.& Raphael, Anthony P.& Sundh, Daniel& Grice, Jeffrey E.& Soyer, Hans Peter& Roberts, Michael S.…[et al.]. 2012. The Human Stratum Corneum Prevents Small Gold Nanoparticle Penetration and Their Potential Toxic Metabolic Consequences. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029266
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, David C.…[et al.]. The Human Stratum Corneum Prevents Small Gold Nanoparticle Penetration and Their Potential Toxic Metabolic Consequences. Journal of Nanomaterials No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1029266
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, David C.& Raphael, Anthony P.& Sundh, Daniel& Grice, Jeffrey E.& Soyer, Hans Peter& Roberts, Michael S.…[et al.]. The Human Stratum Corneum Prevents Small Gold Nanoparticle Penetration and Their Potential Toxic Metabolic Consequences. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1029266
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029266
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر