Therapeutic Approach in the Improvement of Endothelial Dysfunction: The Current State of the Art
المؤلفون المشاركون
Potpara, Tatjana
Prostran, Milica
Radenković, Miroslav
Stojanović, Marko
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-08
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The endothelium has a central role in the regulation of blood flow through continuous modulation of vascular tone.
This is primarily accomplished by balanced release of endothelial relaxing and contractile factors.
The healthy endothelial cells are essential for maintenance of vascular homeostasis involving antioxidant, anti-inflammatory, pro-fibrinolytic, anti-adhesive, or anticoagulant effects.
Oppositely, endothelial dysfunction is primarily characterized by impaired regulation of vascular tone as a result of reduced endothelial nitric oxide (NO) synthase activity, lack of cofactors for NO synthesis, attenuated NO release, or increased NO degradation.
So far, the pharmacological approach in improving/reversal of endothelial dysfunction was shown to be beneficial in clinical trials that have investigated actions of different cardiovascular drugs.
The aim of this paper was to summarize some of the latest clinical findings related to therapeutic possibilities for improving endothelial dysfunction in different pathological conditions.
In the majority of presented clinical investigations, the assessment of improvement or reversal of endothelial dysfunction was performed through the flow-mediated dilatation measurement, and in some of those endothelial progenitor cells’ count was used for the same purpose.
Still, given the fast and continuous development of this field, the evidence acquisition included the MEDLINE data base screening and the selection of articles published between 2010 and 2012.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Radenković, Miroslav& Stojanović, Marko& Potpara, Tatjana& Prostran, Milica. 2013. Therapeutic Approach in the Improvement of Endothelial Dysfunction: The Current State of the Art. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030240
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Radenković, Miroslav…[et al.]. Therapeutic Approach in the Improvement of Endothelial Dysfunction: The Current State of the Art. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030240
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Radenković, Miroslav& Stojanović, Marko& Potpara, Tatjana& Prostran, Milica. Therapeutic Approach in the Improvement of Endothelial Dysfunction: The Current State of the Art. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030240
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030240
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر