Urinary IgG and α2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome
المؤلفون المشاركون
Rizza, Virginia
Casellato, Daniela
Stivali, Gilda
Rachele, Gregorio
Napodano, Pietro
Gallieni, Maurizio
D'Amico, Giuseppe
Bazzi, Claudio
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To assess whether high-molecular-weight proteins excretion predicts outcome and therapy-responsiveness in patients with FSGS and nephrotic syndrome.
Research Design and Methods.
Thirty-eight patients measured at biopsy fractional excretion of IgG (FEIgG) and urinary α2-macroglobulin/creatinine ratio (α2m/C).
Low and high risk groups were defined by cutoffs assessed by ROC analysis.
In all patients first-line therapy was with steroids alone or in combination with cyclophosphamide.
Results.
α2m/C and FEIgG were correlated with segmental sclerosis (r=0.546; r=0.522).
Twenty-three patients (61%) entered Remission and 9 (24%) progressed to ESRD.
Comparing low and high risk groups, by univariate analysis remission was predicted by FEIgG (77% versus 25%, P=0.016) and α2m/C (81% versus 17%, P=0.007) and ESRD at best by FEIgG (0% versus 75%, P<0.0001) and α2m/C (4% versus 67%, P<0.0001).
By multivariate analysis FEIgG was the only independent predictor of remission and α2m/C the most powerful predictor of ESRD.
Low and high risk groups of FEIgG and α2m/C in combination had very high predictive value of sustained remission and ESRD in response to therapy.
Conclusions.
FEIgG and α2m/C are powerful predictors of outcome and responsiveness to steroids and cyclophosphamide; their predictive value, if validated in prospective studies, may be useful in clinical practice suggesting first-line alternative treatments in high risk patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bazzi, Claudio& Rizza, Virginia& Casellato, Daniela& Stivali, Gilda& Rachele, Gregorio& Napodano, Pietro…[et al.]. 2013. Urinary IgG and α2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bazzi, Claudio…[et al.]. Urinary IgG and α2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1031127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bazzi, Claudio& Rizza, Virginia& Casellato, Daniela& Stivali, Gilda& Rachele, Gregorio& Napodano, Pietro…[et al.]. Urinary IgG and α2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر