Association between −308 GA TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome
المؤلفون المشاركون
Di Renzo, Laura
Sarlo, Francesca
Colica, Carmen
Iacopino, L.
Monteleone, G.
De Lorenzo, Antonino
Petramala, Luigi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background and Aim.
Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass.
We evaluated allelic frequency of the G/A −308 TNF-α polymorphism and prevalence of sarcopenia in NWO.
Methods.
We enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A −308 TNF-α polymorphism.
Results.
We found a positive association between sarcopenic obesity and −308 TNF-α polymorphism.
All obese women were sarcopenic and were no carrier of mutation (G/G).
Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P<0.001).
Regarding appendicular skeletal muscle mass index values, 4.21% of NW were sarcopenic (50% G/G and 50% G/A); the same percentage was observed in NWO subjects (100% G/G).
Moreover, 2.10% of PreOB/OB were sarcopenic and all were G/G.
Conclusion.
Our study suggests that TNF-α polymorphism contributes to sarcopenic obesity susceptibility, in association with body composition.
This is the first study that shows the importance of TNF-α polymorphism to determine TBLean variation in NWO syndrome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Di Renzo, Laura& Sarlo, Francesca& Petramala, Luigi& Iacopino, L.& Monteleone, G.& Colica, Carmen…[et al.]. 2013. Association between −308 GA TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome. Disease Markers،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031239
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Di Renzo, Laura…[et al.]. Association between −308 GA TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome. Disease Markers No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1031239
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Di Renzo, Laura& Sarlo, Francesca& Petramala, Luigi& Iacopino, L.& Monteleone, G.& Colica, Carmen…[et al.]. Association between −308 GA TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031239
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031239
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر