Characterization of the Occult Hepatitis B Virus Variants Circulating among the Blood Donors from Eastern India
المؤلفون المشاركون
Datta, Sibnarayan
Chakravarty, Runu
Biswas, Avik
Panigrahi, Rajesh
Chandra, Partha Kumar
Banerjee, Arup
Sekhar, Chakraborti
Pal, Manisha
Chakraborty, Subhashish
Bhattacharya, Prasun
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
A previous study from West Bengal documented very high rate of occult HBV infection (OBI) among the HBsAg negative blood donors.
This study was aimed to characterize the OBI strains circulating among the blood donors and to estimate the risk associated with the prevailing viral variants/mutants.
Blood samples from 2195 voluntary blood donors were included in the study.
HBsAg, HBeAg, anti-HBc, and anti-HBs statuses of the samples were done by ELISA based detection.
PCR amplification and sequencing were done to determine HBV genotypes, basal core promoter (BCP), and precore (Pre-C) mutations.
Among the study samples, 268 were anti-HBc positive/HBsAg negative, among which 65 (24.25%) were HBV DNA positive.
Phylogenetic analysis revealed the presence of HBV/D (87.23%), HBV/A (8.51%), and HBV/C (4.26%) (P<0.0001).HBV/D3 (65.85%) was the significantly prevalent subgenotype over HBV/D2 (26.83%) and HBV/D1 (7.31%) (P=0.0003).
Considerable prevalence of differential BCP (1752C, 1753C, 1762T/1764A, 1753C+1762T/1764A, 1773C, and 1814C) and reverse transcriptase (rt) gene (rtI91L, rtL93P, rtS106C, rtR110G, rtN118T, rtS119T, rtY126H, rtG127W/R, rtC136R, and rtY158H) mutations was identified.
Association of specific HBV subgenotypes with OBI was interesting and needs further study.
Clinically relevant mutations were prevalent among the OBI strains which are of serious concern.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Biswas, Avik& Panigrahi, Rajesh& Chandra, Partha Kumar& Banerjee, Arup& Datta, Sibnarayan& Pal, Manisha…[et al.]. 2013. Characterization of the Occult Hepatitis B Virus Variants Circulating among the Blood Donors from Eastern India. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1032666
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Biswas, Avik…[et al.]. Characterization of the Occult Hepatitis B Virus Variants Circulating among the Blood Donors from Eastern India. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1032666
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Biswas, Avik& Panigrahi, Rajesh& Chandra, Partha Kumar& Banerjee, Arup& Datta, Sibnarayan& Pal, Manisha…[et al.]. Characterization of the Occult Hepatitis B Virus Variants Circulating among the Blood Donors from Eastern India. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1032666
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1032666
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر