Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment
المؤلفون المشاركون
Pawar, Chandrakala R.
Jagdale, Swati C.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Migraine follows circadian rhythm in which headache is more painful at the awakening time.
This needs administration of dosage form at night time to release drug after lag period when pain gets worse.
Sumatriptan succinate is a drug of choice for migraine.
Sumatriptan succinate has bitter taste, low oral bioavailability, and shorter half-life.
Present work deals with application of design of experiment for polyox and xanthan gum in development of press coated floating pulsatile tablet.
Floating pulsatile concept was applied to increase gastric residence of the dosage form.
Burst release was achieved through immediate release tablet using crospovidone as superdisintegrant (10%).
Pulse lag time was achieved using swellable polymer polyox WSR 205 and xanthan gum.
32 experimental design was applied.
Optimized formulation was evaluated for physical characteristics and in-vitro and in-vivo study.
From results, it can be concluded that optimized batch F8 containing polyox WSR205 (72.72%) and xanthan gum (27.27%) of total weight of polymer has shown floating lag time of 55 ± 2 sec, drug content of 100.35 ± 0.4%, hardness of 6 ± 0.1 Kg/cm2, and 98.69 ± 2% drug release in pulse manner with lag time of 7 ± 0.1 h.
Optimized batch showed prolong gastric residence which was confirmed by in-vivo X-ray study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jagdale, Swati C.& Pawar, Chandrakala R.. 2014. Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034496
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jagdale, Swati C.& Pawar, Chandrakala R.. Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034496
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jagdale, Swati C.& Pawar, Chandrakala R.. Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034496
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034496
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر