Contribution of α,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd.
المؤلفون المشاركون
Bresolin, Tania M. B.
Wagner, Theodoro Marcel
Silva, Gislaine F.
Rocha, Lilian W.
Reichert, Simone
Claudino, Vanessa D.
Lucinda-Silva, Ruth M.
Meyre-Silva, Christiane
Cechinel Filho, Valdir
Machado, Marina da Silva
de Souza, Márcia Maria
Malheiros, Angela
Quintão, Nara L. M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The aim of the study was to analyze the constituents of the dichloromethane fraction obtained from A.
moluccana and also to evaluate the anti-inflammatory and antinociceptive properties of α,β-amyrenone isolated from A.
moluccana in mice.
The dichloromethane fraction was evaluated by gas chromatography and submitted to purification.
The mixture of α,β-amyrenone was isolated and then evaluated using the carrageenan-induced paw-oedema or pleurisy and CFA-induced arthritis models in mice.
Five triterpenes, α,β-amyrenone, glutinol, and α,β-amyrin were isolated from dichloromethane fraction of A.
moluccana leaf extract.
The mixture of α,β-amyrenone, dosed orally, was able to reduce mechanical hypersensitivity and paw-oedema induced by carrageenan, interfering with neutrophil migration.
Similar results were observed in the carrageenan-induced pleurisy model.
Repeated administration of the compounds was also effective in reducing the mechanical sensitization and oedema developed in the arthritis model induced by CFA.
In conclusion, the results demonstrate that α,β-amyrenone interferes in both acute and chronic inflammatory processes.
We can infer that these effects involve, at least in part, a reduction in the neutrophil migration.
Therefore, it seems reasonable to suggest that α,β-amyrenone could represent a new therapeutic tool for the management of painful and inflammatory diseases, especially those presenting a chronic profile.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Quintão, Nara L. M.& Rocha, Lilian W.& Silva, Gislaine F.& Reichert, Simone& Claudino, Vanessa D.& Lucinda-Silva, Ruth M.…[et al.]. 2014. Contribution of α,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd.. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034519
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Quintão, Nara L. M.…[et al.]. Contribution of α,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd.. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034519
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Quintão, Nara L. M.& Rocha, Lilian W.& Silva, Gislaine F.& Reichert, Simone& Claudino, Vanessa D.& Lucinda-Silva, Ruth M.…[et al.]. Contribution of α,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd.. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034519
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034519
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر