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A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy
المؤلفون المشاركون
Caretto, Amelia
Primerano, Liviana
Novara, Francesca
Genovese, Stefano
Rondinelli, Maurizio
Zuffardi, Orsetta
المصدر
Case Reports in Obstetrics and Gynecology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-25
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Liddle’s syndrome (LS) is a rare heritable form of hypertension that often affects young patients.
It is caused by gain-of-function mutations of the kidney epithelial sodium channel (ENaC) and it is classically associated with hypokalemia and suppression of renin and aldosterone.
LS is characterized by responsiveness to ENaC inhibitors but not to mineralocorticoid receptor inhibitors.
Consequently the most effective treatment is amiloride.
This drug is not used in pregnancy, as it has not been sufficiently studied during gestation.
However for pregnant LS patient amiloride is the most effective drug in decreasing blood pressure.
Herein we report the case of a LS patient, who has been followed up by a multidisciplinary teamwork during her first pregnancy.
Hypertension worsened after the 25th week of gestation and amiloride was safely administered, firstly in combination with hydrochlorothiazide (the only formulation commercially available in Italy) and, thereafter, as a single drug.
Genetic testing was performed in the patient’s family in order to support diagnosis and clinical management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Caretto, Amelia& Primerano, Liviana& Novara, Francesca& Zuffardi, Orsetta& Genovese, Stefano& Rondinelli, Maurizio. 2014. A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy. Case Reports in Obstetrics and Gynecology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034835
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Caretto, Amelia…[et al.]. A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy. Case Reports in Obstetrics and Gynecology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1034835
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Caretto, Amelia& Primerano, Liviana& Novara, Francesca& Zuffardi, Orsetta& Genovese, Stefano& Rondinelli, Maurizio. A Therapeutic Challenge: Liddle’s Syndrome Managed with Amiloride during Pregnancy. Case Reports in Obstetrics and Gynecology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034835
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034835
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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