Prediabetes Is Associated with HNF-4α P2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis
المؤلفون المشاركون
Zhang, Tao
Wang, Changyi
Chen, Sihan
Chen, Zhongwei
Liu, Shengyuan
Peng, Xiaolin
Ma, Jianping
Zhong, Xiaohong
Yan, Yanqiong
Tang, Linlin
Mai, Yifeng
Han, Liyuan
Duan, Shiwei
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Controversy remains for the association between hepatocyte nuclear factor 4α (HNF-4α) P2 promoter polymorphism rs1884613 and type 2 diabetes (T2D).
There was no association test of this polymorphism with prediabetes and T2D in the Chinese population.
Moreover, an updated meta-analysis in various ethnic groups is needed to establish the contribution of rs1884613 to T2D risk.
Methods.
Using the Sequenom MassARRAY platform approach, we genotyped rs1884613 of HNF-4α in the P2 promoter region among 490 T2D patients, 471 individuals with prediabetes, and 575 healthy controls.
All the individuals were recruited from 16 community health service centers in Nanshan district in Shenzhen province.
Using STATA 11.0 software, meta-analysis was performed to summarize the overall contribution of rs1884613 to T2D risk.
Results.
Polymorphism rs1884613 was associated with genetic susceptibility to prediabetes in the whole samples (OR = 1.40, 95% CI = 1.16–1.68, P=0.0001) and the female subgrouped samples (OR = 1.48, 95% CI = 1.14–1.92, P=0.003) after adjusting for age and body mass index (BMI).
In contrast, there was no association of rs1884613 with T2D in the whole samples and male in our case-control study and meta-analysis.
Conclusions.
Our results suggest that rs1884613 contributes to susceptibility to prediabetes, whereas this polymorphism may not play an important role in the development of T2D.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Changyi& Chen, Sihan& Zhang, Tao& Chen, Zhongwei& Liu, Shengyuan& Peng, Xiaolin…[et al.]. 2014. Prediabetes Is Associated with HNF-4α P2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035050
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Changyi…[et al.]. Prediabetes Is Associated with HNF-4α P2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035050
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Changyi& Chen, Sihan& Zhang, Tao& Chen, Zhongwei& Liu, Shengyuan& Peng, Xiaolin…[et al.]. Prediabetes Is Associated with HNF-4α P2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035050
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035050
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر