Effects of Modified Simiao Decoction on IL-1β and TNFα Secretion in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation
المؤلفون المشاركون
Hu, Yonghong
Liu, Yafei
Chen, Zhe
Tu, Shenghao
Wang, Yu
Dong, Hui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Simiao pill, a Chinese herbal formula containing four herbs, has been used in the treatment of gouty arthritis for many years.
The aim of this study was to explore the effects of modified Simiao decoction (MSD) on IL-1β and TNFα secretion in monocytic THP-1 cells with monosodium urate (MSU) crystals-induced inflammation.
The MSU crystals-induced inflammation model in THP-1 cells was successfully established by the stimulation of phorbol 12-myristate 13-acetate (PMA) and MSU crystals.
Then, the MSD-derived serum or control serum extracted from rat was administered to different treatment groups.
The morphology of MSU crystals and THP-1 cells was observed.
IL-1β and TNFα protein expression in supernatant of THP-1 cells were determined by ELISA.
Our data demonstrated that MSU crystals induced time-dependent increase of IL-1β and TNFα.
Moreover, MSD significantly decreased IL-1β release in THP-1 cells with MSU crystals-induced inflammation.
These results suggest that MSD is promising in the treatment of MSU crystals-induced inflammation in THP-1 cells.
MSD may act as an anti-IL-1 agent in treating gout.
The underlying mechanism may be related to NALP3 inflammasome which needs to be validated in future studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yafei& Tu, Shenghao& Chen, Zhe& Wang, Yu& Hu, Yonghong& Dong, Hui. 2014. Effects of Modified Simiao Decoction on IL-1β and TNFα Secretion in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035187
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yafei…[et al.]. Effects of Modified Simiao Decoction on IL-1β and TNFα Secretion in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035187
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yafei& Tu, Shenghao& Chen, Zhe& Wang, Yu& Hu, Yonghong& Dong, Hui. Effects of Modified Simiao Decoction on IL-1β and TNFα Secretion in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035187
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035187
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر