An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease
المؤلفون المشاركون
Chen, Huey-Yi
Chen, Wen-Chi
Man, Kee-Ming
Lin, Wei-Yun
Wu, San-Yuan
Tsai, Kao-Sung
Lee, Yuan-Ju
Shen, Jui-Lung
Tsai, Fuu-Jen
Chen, Yung-Hsiang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Pharmacological therapy for urolithiasis using medicinal plants has been increasingly adopted for the prevention of its recurrence.
A Drosophila melanogaster model developed for translational research of urolithiasis was applied to evaluate agents with potential antilithic effects and calcium oxalate (CaOx) formation.
Potential antilithic herbs were prepared in a mixture of food in a diluted concentration of 5,000 from the original extract with 0.5% ethylene glycol (EG) as the lithogenic agent.
The control group was fed with food only.
After 3 weeks, flies ( n ≥ 150 for each group) were killed using CO2 narcotization, and the Malpighian tubules were dissected, removed, and processed for polarized light microscopy examination of the crystals.
The crystal formation rate in the EG group was 100.0%.
In the study, 16 tested herbal drugs reached the crystal formation rate of 0.0%, including Salviae miltiorrhizae, Paeonia lactiflora, and Carthami flos.
Scutellaria baicalensis enhanced CaOx crystal formation.
Two herbal drugs Commiphora molmol and Natrii sulfas caused the death of all flies.
Our rapid screening methods provided evidence that some medicinal plants have potential antilithic effects.
These useful medicinal plants can be further studied using other animal or human models to verify their effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, San-Yuan& Shen, Jui-Lung& Man, Kee-Ming& Lee, Yuan-Ju& Chen, Huey-Yi& Chen, Yung-Hsiang…[et al.]. 2014. An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035510
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, San-Yuan…[et al.]. An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035510
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, San-Yuan& Shen, Jui-Lung& Man, Kee-Ming& Lee, Yuan-Ju& Chen, Huey-Yi& Chen, Yung-Hsiang…[et al.]. An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035510
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1035510
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر