G αs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer

المؤلفون المشاركون

Jin, Gui-hua
Guo, Xi-jing
Wang, Li-juan
Li, Meng
Ying, Xia
Zhu, Qing
He, Chenchen
Zhou, Xia
Wang, Le
Wu, Huili

المصدر

Journal of Immunology Research

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-03-31

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأحياء

الملخص EN

Background.

T393C polymorphism in the gene GNAS1, which encodes the G-protein alpha s subunit (Gαs) of heterotrimeric G protein, is significantly associated with the clinical outcome of patients suffering from several cancers.

However, studies on the role and protein expression of Gαs subunit in prostate cancer were still unavailable.

Methods.

The immunohistochemical staining was used to assess Gαs expression through tissue microarray procedure of 56 metastatic PCas, 291 localized PCas, and 67 benign hyperplasia (BPH).

Gαs expression was semiquantitatively scored and evaluated the correlation with pathologic parameters and biochemical recurrence of prostate-specific antigen (PSA).

Results.

Gαs expression was localized in nuclear and cytoplasm in prostate cancer cells and downregulated in metastatic PCa compared to localized PCa and BPH ( P < 0.001 ) .

Gαs was inversely associated with PSA level and Gleason scores; patients with low expression of Gαs had adverse clincopathological features.

In multivariable Cox regression analysis, high Gαs expression and Gleason scores were independent predictors of both PSA progression-free and overall survival.

Conclusions.

Gαs down-expression is associated with adverse pathologic features and clinical PSA biochemical recurrence of prostate cancer.

Gαs is an independent predictor to help determine the risk of PSA progression and death.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Li-juan& Jin, Gui-hua& He, Chenchen& Guo, Xi-jing& Zhou, Xia& Li, Meng…[et al.]. 2014. G αs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040830

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Li-juan…[et al.]. G αs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer. Journal of Immunology Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040830

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Li-juan& Jin, Gui-hua& He, Chenchen& Guo, Xi-jing& Zhou, Xia& Li, Meng…[et al.]. G αs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040830

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1040830