Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene
المؤلف
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-09
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Exemplified by cancer cells’ preference for glycolysis, for example, the Warburg effect, altered metabolism in tumorigenesis has emerged as an important aspect of cancer in the past 10–20 years.
Whether due to changes in regulatory tumor suppressors/oncogenes or by acting as metabolic oncogenes themselves, enzymes involved in the complex network of metabolic pathways are being studied to understand their role and assess their utility as therapeutic targets.
Conversion of glycolytic intermediate 3-phosphoglycerate into phosphohydroxypyruvate by the enzyme phosphoglycerate dehydrogenase (PHGDH)—a rate-limiting step in the conversion of 3-phosphoglycerate to serine—represents one such mechanism.
Forgotten since classic animal studies in the 1980s, the role of PHGDH as a potential therapeutic target and putative metabolic oncogene has recently reemerged following publication of two prominent papers near-simultaneously in 2011.
Since that time, numerous studies and a host of metabolic explanations have been put forward in an attempt to understand the results observed.
In this paper, I review the historic progression of our understanding of the role of PHGDH in cancer from the early work by Snell through its reemergence and rise to prominence, culminating in an assessment of subsequent work and what it means for the future of PHGDH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zogg, Cheryl K.. 2014. Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene. Journal of Oncology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zogg, Cheryl K.. Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene. Journal of Oncology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1042246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zogg, Cheryl K.. Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر