The Efficacy of Bisphosphonates in Preventing Aromatase Inhibitor Induced Bone Loss for Postmenopausal Women with Early Breast Cancer: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Anagha, Pooleriveetil Padikkal
Sen, Suchandra
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objectives.
We aim to determine the efficacy of bisphosphonates in preventing aromatase inhibitor induced bone loss (AIBL) in postmenopausal women with early breast cancer.
The secondary objective was to determine the safety of bisphosphonates.
Materials and Methods.
We searched electronic databases in a time period of 1995 January to 2013 June.
Random effects meta-analytical models were used; between study heterogeneity and publication bias was assessed.
Results.
A total of six eligible studies reported the BMD T score of LS at 12 months and from that 3 trials of Zoledronic acid compared the change in BMD in immediate ZOL versus delayed ZOL done with subgroups like patients with normal BMD at baseline (OR = 5.402, 95% CI = 1.329–21.959, P value = 0.018) and osteopenic BMD at baseline (OR = 4.008, 95% CI = 2.249–7.143, P value = 0.0002).
Both had a significant decrease in BMD that favoured the delayed ZOL; 3 trials of risedronate and ibandronate also had a significant decrease in BMD in AIs alone group.
Immediate ZOL versus delayed ZOL also showed increased risk of getting an ADR in immediate group.
Conclusion.
Third generation bisphosphonates has an effect on BMD of patients who are on treatment of AIs in breast cancer.
Furthermore, the patients treated with immediate ZOL had a significantly high risk of musculoskeletal ADR’s than patients with delayed ZOL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Anagha, Pooleriveetil Padikkal& Sen, Suchandra. 2014. The Efficacy of Bisphosphonates in Preventing Aromatase Inhibitor Induced Bone Loss for Postmenopausal Women with Early Breast Cancer: A Systematic Review and Meta-Analysis. Journal of Oncology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042266
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Anagha, Pooleriveetil Padikkal& Sen, Suchandra. The Efficacy of Bisphosphonates in Preventing Aromatase Inhibitor Induced Bone Loss for Postmenopausal Women with Early Breast Cancer: A Systematic Review and Meta-Analysis. Journal of Oncology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1042266
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Anagha, Pooleriveetil Padikkal& Sen, Suchandra. The Efficacy of Bisphosphonates in Preventing Aromatase Inhibitor Induced Bone Loss for Postmenopausal Women with Early Breast Cancer: A Systematic Review and Meta-Analysis. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042266
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042266
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر