Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study
المؤلفون المشاركون
Andersen, Stine Linding
Laurberg, Peter
Nygaard, Birte
Andersen, Stig
Carlé, Allan
Karmisholt, Jesper
Krejbjerg, Anne
Pedersen, Inge Bülow
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Graves’ disease may have a number of clinical manifestations with varying degrees of activity that may not always run in parallel.
Objectives.
To study associations between serum levels of TSH-receptor autoantibodies and the three main manifestations of Graves’ disease (hyperthyroidism, goiter, and presence of orbitopathy) at the time of diagnosis of hyperthyroidism.
Methods.
We describe a cohort of 208 patients with newly diagnosed Graves’ hyperthyroidism.
Patients were enrolled in a multiphase study of antithyroid drug therapy of Graves’ hyperthyroidism, entitled “Remission Induction and Sustenance in Graves’ Disease (RISG).” Patients were systematically tested for degree of biochemical hyperthyroidism, enlarged thyroid volume by ultrasonography, and the presence of orbitopathy.
Results.
Positive correlations were found between the levels of TSH-receptor autoantibodies in serum and the three manifestations of Graves’ disease: severeness of hyperthyroidism, presence of enlarged thyroid, and presence of orbitopathy, as well as between the different types of manifestations.
Only around half of patients had enlarged thyroid gland at the time of diagnosis of hyperthyroidism, whereas 25–30% had orbitopathy.
Conclusions.
A positive but rather weak correlation was found between TSH-receptor antibodies in serum and the major clinical manifestation of Graves’ disease.
Only half of the patients had an enlarged thyroid gland at the time of diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Laurberg, Peter& Nygaard, Birte& Andersen, Stig& Carlé, Allan& Karmisholt, Jesper& Krejbjerg, Anne…[et al.]. 2014. Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study. Journal of Thyroid Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043256
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Laurberg, Peter…[et al.]. Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study. Journal of Thyroid Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043256
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Laurberg, Peter& Nygaard, Birte& Andersen, Stig& Carlé, Allan& Karmisholt, Jesper& Krejbjerg, Anne…[et al.]. Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study. Journal of Thyroid Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043256
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043256
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر