Acute Exercise-Induced Response of Monocyte Subtypes in Chronic Heart and Renal Failure
المؤلفون المشاركون
Van Craenenbroeck, Emeline M.
Van Ackeren, Katrijn
Hoymans, Vicky Y.
Roeykens, Johan
Verpooten, Gert A.
Vrints, Christiaan J.
Couttenye, Marie M.
Van Craenenbroeck, Amaryllis H.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
Monocytes (Mon1-2-3) play a substantial role in low-grade inflammation associated with high cardiovascular morbidity and mortality of patients with chronic kidney disease (CKD) and chronic heart failure (CHF).
The effect of an acute exercise bout on monocyte subsets in the setting of systemic inflammation is currently unknown.
This study aims (1) to evaluate baseline distribution of monocyte subsets in CHF and CKD versus healthy subjects (HS) and (2) to evaluate the effect of an acute exercise bout.
Exercise-induced IL-6 and MCP-1 release are related to the Mon1-2-3 response.
Methods.
Twenty CHF patients, 20 CKD patients, and 15 HS were included.
Before and after a maximal cardiopulmonary exercise test, monocyte subsets were quantified by flow cytometry: CD14++CD16−CCR2+ (Mon1), CD14++CD16+CCR2+ (Mon2), and CD14+CD16++CCR2− (Mon3).
Serum levels of IL-6 and MCP-1 were determined by ELISA.
Results.
Baseline distribution of Mon1-2-3 was comparable between the 3 groups.
Following acute exercise, %Mon2 and %Mon3 increased significantly at the expense of a decrease in %Mon1 in HS and in CKD.
This response was significantly attenuated in CHF (P<0.05).
In HS only, MCP-1 levels increased following exercise; IL-6 levels were unchanged.
Circulatory power was a strong and independent predictor of the changes in Mon1 (β=-0.461, P<0.001) and Mon3 (β=0.449, P<0.001); and baseline LVEF of the change in Mon2 (β=0.441, P<0.001).
Conclusion.
The response of monocytes to acute exercise is characterized by an increase in proangiogenic and proinflammatory Mon2 and Mon3 at the expense of phagocytic Mon1.
This exercise-induced monocyte subset response is mainly driven by hemodynamic changes and not by preexistent low-grade inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Van Craenenbroeck, Amaryllis H.& Van Ackeren, Katrijn& Hoymans, Vicky Y.& Roeykens, Johan& Verpooten, Gert A.& Vrints, Christiaan J.…[et al.]. 2014. Acute Exercise-Induced Response of Monocyte Subtypes in Chronic Heart and Renal Failure. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Van Craenenbroeck, Amaryllis H.…[et al.]. Acute Exercise-Induced Response of Monocyte Subtypes in Chronic Heart and Renal Failure. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Van Craenenbroeck, Amaryllis H.& Van Ackeren, Katrijn& Hoymans, Vicky Y.& Roeykens, Johan& Verpooten, Gert A.& Vrints, Christiaan J.…[et al.]. Acute Exercise-Induced Response of Monocyte Subtypes in Chronic Heart and Renal Failure. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر