Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients
المؤلفون المشاركون
Nadkar, Milind
Umare, Vinod
Pradhan, Vandana
Rajadhyaksha, Anjali
Patwardhan, Manisha
Ghosh, Kanjaksha
Nadkarni, Anita
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Systemic lupus erythematosus (SLE) is an inflammatory rheumatic disease characterized by production of autoantibodies and organ damage.
Elevated levels of cytokines have been reported in SLE patients.
In this study we have investigated the effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in 145 Indian SLE patients.
One hundred and forty-five healthy controls of the same ethnicity served as a control group.
Clinical disease activity was scored according to SLEDAI score.
Accordingly, 110 patients had active disease and 35 patients had inactive disease.
Mean levels of IL-6, TNF-α, and IL-1β were found to be significantly higher in SLE patients than healthy controls (P<0.001).
Mean level of IL-6 for patients with active disease (70.45±68.32 pg/mL) was significantly higher (P=0.0430) than those of inactive disease patients (43.85±63.36 pg/mL).
Mean level of TNF-α was 44.76±68.32 pg/mL for patients with active disease while it was 25.97±22.03 pg/mL for those with inactive disease and this difference was statistically significant (P=0.0161).
Similar results were obtained for IL-1β (P=0.0002).
Correlation between IL-6, TNF-α, and IL-1β serum levels and SLEDAI score was observed (r=0.20, r=0.27, and r=0.38, resp.).
This study supports the role of these proinflammatory cytokines as inflammatory mediators in active stage of disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Umare, Vinod& Pradhan, Vandana& Nadkar, Milind& Rajadhyaksha, Anjali& Patwardhan, Manisha& Ghosh, Kanjaksha…[et al.]. 2014. Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043517
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Umare, Vinod…[et al.]. Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043517
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Umare, Vinod& Pradhan, Vandana& Nadkar, Milind& Rajadhyaksha, Anjali& Patwardhan, Manisha& Ghosh, Kanjaksha…[et al.]. Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043517
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043517
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر