GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis
المؤلفون المشاركون
Dahmen, Uta
Zhang, Hui
Wang, Wenjie
Fang, Haoshu
Yang, Yan
Li, Xiaolan
He, Junli
Jiang, Xiaojing
Wang, Weipeng
Liu, Shenpei
Hu, Jifa
Dirsch, Olaf
Liu, Anding
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Liver dysfunction has been known to occur frequently in cases of sepsis.
Excessive inflammation and apoptosis are pathological features of acute liver failure.
Recent studies suggest that activation of glycogen synthase kinase- (GSK-) 3β is involved in inflammation and apoptosis.
We aimed to investigate the protective effects of GSK-3β inhibition on polymicrobial sepsis-induced liver injury and to explore the possible mechanisms.
Polymicrobial sepsis was induced by cecal ligation and puncture (CLP), and SB216763 was used to inhibit GSK-3β in C57BL/6 mice.
GSK-3β was activated following CLP.
Administration of SB216763 decreased mortality, ameliorated liver injury, and reduced hepatic apoptosis.
The inhibition of GSK-3β also reduced leukocyte infiltration and hepatic inflammatory cytokine expression and release.
Moreover, GSK-3β inhibition suppressed the transcriptional activity of nuclear factor-kappa B (NF-κB) but enhanced the transcriptional activity of cAMP response element binding protein (CREB) in the liver.
In in vitro studies, GSK-3β inhibition reduced inflammatory cytokine production via modulation of NF-κB and CREB signaling pathways in lipopolysaccharide-stimulated macrophages.
In conclusion, these findings suggest that GSK-3β blockade protects against CLP-induced liver via inhibition of inflammation by modulating NF-κB and CREB activity and suppression of hepatic apoptosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Hui& Wang, Wenjie& Fang, Haoshu& Yang, Yan& Li, Xiaolan& He, Junli…[et al.]. 2014. GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043691
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Hui…[et al.]. GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043691
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Hui& Wang, Wenjie& Fang, Haoshu& Yang, Yan& Li, Xiaolan& He, Junli…[et al.]. GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043691
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043691
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر