Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial
المؤلفون المشاركون
Currier, Judith
Boger, M. Sean
Hulgan, Todd
Liao, Diana H.
McComsey, Grace A.
Mangili, Alexandra
Walmsley, Sharon L.
McCreath, Heather
Milne, Ginger L.
Sanchez, Stephanie C.
Lake, Jordan E.
Wanke, Christine A.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Chronic inflammation is a hallmark of HIV infection.
Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters.
Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects.
We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2 (PGE-M), prostacyclin (PGI-M), and thromboxane B2 (TxB2) in HIV-infected women switching to RAL-containing antiretroviral therapy (ART).
Thirty-seven women (RAL = 17; PI/NNRTI = 20) with a median age of 43 years and BMI 32 kg/m2 completed week 24.
TxB2 increased in the RAL versus PI/NNRTI arm (+0.09 versus −0.02; P = 0.06 ).
Baseline PGI-M was lower in the RAL arm ( P = 0.005 ); no other between-arm cross-sectional differences were observed.
In the PI/NNRTI arm, 24-week visceral adipose tissue change correlated with PGI-M ( rho = 0.45 ; P = 0.04 ) and TxB2 ( rho = 0.44 ; P = 0.005 ) changes, with a trend seen for PGE-M ( rho = 0.41 ; P = 0.07 ).
In an adjusted model, age ≥ 50 years ( N = 8 ) was associated with increased PGE-M (P = 0.04 ).
In this randomized trial, a switch to RAL did not significantly affect urinary eicosanoids over 24 weeks.
In women continuing PI/NNRTI, increased visceral adipose tissue correlated with increased PGI-M and PGE-M.
Older age (≥50) was associated with increased PGE-M.
Relationships between aging, adiposity, ART, and eicosanoids during HIV-infection require further study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hulgan, Todd& Boger, M. Sean& Liao, Diana H.& McComsey, Grace A.& Wanke, Christine A.& Mangili, Alexandra…[et al.]. 2014. Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043814
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hulgan, Todd…[et al.]. Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043814
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hulgan, Todd& Boger, M. Sean& Liao, Diana H.& McComsey, Grace A.& Wanke, Christine A.& Mangili, Alexandra…[et al.]. Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043814
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043814
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر