Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner
المؤلفون المشاركون
Streck, Emilio Luiz
de Souza, Cláudio T.
Lira, Fábio Santos
Caperuto, Erico Chagas
Oliveira, Nara R. C.
Marques, Scherolin O.
Luciano, Thais F.
Pauli, José R.
Moura, Leandro P.
Pieri, Bruno L. S.
Engelmann, Julia
Scaini, Gisele
Pinho, Ricardo A.
Ropelle, Eduardo R.
Silva, Adelino S. R.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The present study investigated the effects of running at 0.8 or 1.2 km/h on inflammatory proteins (i.e., protein levels of TNF-α, IL-1β, and NF-κB) and metabolic proteins (i.e., protein levels of SIRT-1 and PGC-1α, and AMPK phosphorylation) in quadriceps of rats.
Male Wistar rats at 3 (young) and 18 months (middle-aged rats) of age were divided into nonexercised (NE) and exercised at 0.8 or 1.2 km/h.
The rats were trained on treadmill, 50 min per day, 5 days per week, during 8 weeks.
Forty-eight hours after the last training session, muscles were removed, homogenized, and analyzed using biochemical and western blot techniques.
Our results showed that: (a) running at 0.8 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with NE rats; (b) these responses were lower for the inflammatory proteins and higher for the metabolic proteins in young rats compared with middle-aged rats; (c) running at 1.2 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with 0.8 km/h; (d) these responses were similar between young and middle-aged rats when trained at 1.2 km.
In summary, the age-related increases in inflammatory proteins, and the age-related declines in metabolic proteins can be reversed and largely improved by treadmill training.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oliveira, Nara R. C.& Marques, Scherolin O.& Luciano, Thais F.& Pauli, José R.& Moura, Leandro P.& Caperuto, Erico Chagas…[et al.]. 2014. Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043962
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oliveira, Nara R. C.…[et al.]. Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043962
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oliveira, Nara R. C.& Marques, Scherolin O.& Luciano, Thais F.& Pauli, José R.& Moura, Leandro P.& Caperuto, Erico Chagas…[et al.]. Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043962
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043962
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر