Downregulated GABA and BDNF-TrkB Pathway in Chronic Cyclothiazide Seizure Model
المؤلفون المشاركون
Kong, Shuzhen
Cheng, Zhihua
Liu, Jianhui
Wang, Yun
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons.
It has also been shown to acutely induce epileptic seizure behavior in freely moving rats.
However, whether CTZ induced seizure rats could develop to have recurrent seizure still remains unknown.
In the current study, we demonstrated that 46% of the CTZ induced seizure rats developed to have recurrent seizure behavior as well as epileptic EEG with a starting latency between 2 weeks and several months.
In those chronic seizure rats 6 months after the seizure induction by the CTZ, our immunohistochemistry results showed that both GAD and GAT-1 were significantly decreased across CA1, CA3, and dentate gyrus area of the hippocampus studied.
In addition, both BDNF and its receptor TrkB were also decreased in hippocampus of the chronic CTZ seizure rats.
Our results indicate that CTZ induced seizure is capable of developing to have recurrent seizure, and the decreased GABA synthesis and transport as well as the impaired BDNF-TrkB signaling pathway may contribute to the development of the recurrent seizure.
Thus, CTZ seizure rats may provide a novel animal model for epilepsy study and anticonvulsant drug testing in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kong, Shuzhen& Cheng, Zhihua& Liu, Jianhui& Wang, Yun. 2014. Downregulated GABA and BDNF-TrkB Pathway in Chronic Cyclothiazide Seizure Model. Neural Plasticity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1046675
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kong, Shuzhen…[et al.]. Downregulated GABA and BDNF-TrkB Pathway in Chronic Cyclothiazide Seizure Model. Neural Plasticity No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1046675
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kong, Shuzhen& Cheng, Zhihua& Liu, Jianhui& Wang, Yun. Downregulated GABA and BDNF-TrkB Pathway in Chronic Cyclothiazide Seizure Model. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1046675
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046675
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر