Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity
المؤلفون المشاركون
Regensburger, Martin
Prots, Iryna
Winner, Beate
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In Parkinson’s disease (PD) and other synucleinopathies, chronic neurodegeneration occurs within different areas of the central nervous system leading to progressive motor and nonmotor symptoms.
The symptomatic treatment options that are currently available do not slow or halt disease progression.
This highlights the need of a better understanding of disease mechanisms and disease models.
The generation of newborn neurons in the adult hippocampus and in the subventricular zone/olfactory bulb system is affected by many different regulators and possibly involved in memory processing, depression, and olfaction, symptoms which commonly occur in PD.
The pathology of the adult neurogenic niches in human PD patients is still mostly elusive, but different preclinical models have shown profound alterations of adult neurogenesis.
Alterations in stem cell proliferation, differentiation, and survival as well as neurite outgrowth and spine formation have been related to different aspects in PD pathogenesis.
Therefore, neurogenesis in the adult brain provides an ideal model to study disease mechanisms and compounds.
In addition, adult newborn neurons have been proposed as a source of endogenous repair.
Herein, we review current knowledge about the adult neurogenic niches in PD and highlight areas of future research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Regensburger, Martin& Prots, Iryna& Winner, Beate. 2014. Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity. Neural Plasticity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046695
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Regensburger, Martin…[et al.]. Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity. Neural Plasticity No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1046695
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Regensburger, Martin& Prots, Iryna& Winner, Beate. Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046695
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046695
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر