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Apathy in Alzheimer’s Disease: Any Effective Treatment?
المؤلفون المشاركون
Amenta, Francesco
Fasanaro, Angiola M.
Traini, Enea
Rea, Raffaele
Carotenuto, Anna
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Objective.
This review has evaluated the effectiveness of pharmacological treatment of apathy in patients with Alzheimer’s disease (AD).
Methods.
A systematic literature search was conducted on published clinical trials assessing the effects of pharmacological treatment on apathy in AD over the last 10 years.
Results.
Fourteen studies considered of good quality were included in the analysis (4 randomized controlled trials, 9 open-label studies, and 1 retrospective analysis).
Cholinesterase inhibitors were investigated in 9 studies, monoaminergic compounds such as methylphenidate and modafinil in two trials and one trial, respectively, and Ginkgo biloba (EGb 761 extract) and citalopram in one study each.
Cholinesterase inhibitors did not show statistical significant effect in 1 RCT study but were associated to improvement in 3 open-label studies.
Methylphenidate elicited a small but significant activity accompanied by relevant side effects such as high blood pressure, cough, and osteoarticular pain.
EGb 761 was well tolerated and countered apathy.
Other treatments induced modest improvements or were ineffective.
Conclusions.
Apathy treatment remains a challenge and there is no evident advantage of any specific pharmacotherapy tested so far.
The development of controlled studies according to updated guidelines for the diagnosis of apathy in patients with AD is desirable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rea, Raffaele& Carotenuto, Anna& Fasanaro, Angiola M.& Traini, Enea& Amenta, Francesco. 2014. Apathy in Alzheimer’s Disease: Any Effective Treatment?. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rea, Raffaele…[et al.]. Apathy in Alzheimer’s Disease: Any Effective Treatment?. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1049574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rea, Raffaele& Carotenuto, Anna& Fasanaro, Angiola M.& Traini, Enea& Amenta, Francesco. Apathy in Alzheimer’s Disease: Any Effective Treatment?. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1049574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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