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Comparison of β-Propiolactone and Formalin Inactivation on Antigenicity and Immune Response of West Nile Virus
المؤلفون المشاركون
Mahanta, Jagadish
Khan, Siraj A.
Topno, Rashmee
Chowdhury, Pritom
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-27
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
West Nile Virus (WNV) is a pathogenic arbovirus that belongs to genus Flavivirus under family Flaviviridae.
Till now there are no approved vaccines against WNV for human use.
In this study, the effect of two alkylating agents, formaldehyde and β-PL, generally used for inactivated vaccine preparation, was assessed on the basis of antigenic and immunogenic potential of the inactivated WNV.
Lineage 5 WNV isolates were inactivated by both formalin and β-PL treatments.
Inactivation was confirmed by repeated passage in BHK-21 cell line and infant mice.
Viruses inactivated by both the treatments showed higher antigenicity.
Immune response in mice model showed serum anti-WNV antibody titre was moderately higher in formalin inactivated antigen compared to β-PL inactivated antigen.
However, no significant differences were observed in neutralization antibody titre.
In conclusion, we can state that both formaldehyde and β-PL inactivation processes were found to be equally efficient for inactivation of WNV.
However, they need to be compared with other inactivating agents along with study on cell mediated immune response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chowdhury, Pritom& Topno, Rashmee& Khan, Siraj A.& Mahanta, Jagadish. 2015. Comparison of β-Propiolactone and Formalin Inactivation on Antigenicity and Immune Response of West Nile Virus. Advances in Virology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054029
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chowdhury, Pritom…[et al.]. Comparison of β-Propiolactone and Formalin Inactivation on Antigenicity and Immune Response of West Nile Virus. Advances in Virology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1054029
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chowdhury, Pritom& Topno, Rashmee& Khan, Siraj A.& Mahanta, Jagadish. Comparison of β-Propiolactone and Formalin Inactivation on Antigenicity and Immune Response of West Nile Virus. Advances in Virology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054029
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054029
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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