SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson’s Disease in Chinese and Australians
المؤلفون المشاركون
Huang, Yue
Rowe, Dominic
Wang, Ying
Kwok, John B. J.
Xiao, Qin
Mastaglia, Frank
Halliday, Glenda
Wang, Gang
Liu, Jun
Chen, Sheng-Di
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
α-Synuclein (SNCA) and microtubule-associated protein tau (MAPT) are the two major genes independently, but not jointly, associated with susceptibility for Parkinson’s disease (PD).
The SNCA gene has recently been identified as a major modifier of age of PD onset.
Whether MAPT gene synergistically influences age of onset of PD is unknown.
Objective.
To investigate independent and joint effects of MAPT and SNCA on PD onset age.
Methods.
412 patients with PD were recruited from the Australian PD Research Network (123) and the Neurology Department, Ruijin Hospital Affiliated to Shanghai Jiaotong University, China (289).
MAPT (rs17650901) tagging H1/H2 haplotype and SNCA (Rep1) were genotyped in the Australian cohort, and MAPT (rs242557, rs3744456) and SNCA (rs11931074, rs894278) were genotyped in the Chinese cohort.
SPSS regression analysis was used to test genetic effects on age at onset of PD in each cohort.
Results.
SNCA polymorphisms associated with the onset age of PD in both populations.
MAPT polymorphisms did not enhance such association in either entire cohort.
Conclusion.
This study suggests that, in both ethnic groups, SNCA gene variants influence the age at onset of PD and α-synuclein plays a key role in the disease course of PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Yue& Wang, Gang& Rowe, Dominic& Wang, Ying& Kwok, John B. J.& Xiao, Qin…[et al.]. 2015. SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson’s Disease in Chinese and Australians. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054314
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Yue…[et al.]. SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson’s Disease in Chinese and Australians. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054314
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Yue& Wang, Gang& Rowe, Dominic& Wang, Ying& Kwok, John B. J.& Xiao, Qin…[et al.]. SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson’s Disease in Chinese and Australians. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054314
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054314
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر