Application of Long-Acting VLHL PAI-1 during Sutureless Partial Nephrectomy in Mice Reduces Bleeding
المؤلفون المشاركون
Shahrour, Khaled
Keck, Rick
Jankun, Jerzy
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
PAI-1 prevents lysis of blood clot by inhibiting the urokinase and tPA induced conversion of plasminogen to plasmin.
VLHL PAI-1 protein mutant was created to extend half-life over 700 hours.
The objective of this paper was to test VLHL PAI-1 effects on bleeding during partial nephrectomy in mice.
All animals had a left partial nephrectomy after intravenous infusion of saline or tPA.
The animals were divided into four groups.
Group 1 was infused with saline and kidney was exposed to saline too; Group 2 was infused with saline and kidney was exposed to PAI-1.
Group 3 was infused with tPA and kidney was exposed to saline, while Group 4 was infused with tPA and kidney was exposed to PAI-1.
Preweighed gauze containing PAI-1 or saline was then applied to the kidney for 30 minutes.
The gauze was afterward weighed and blood loss was measured by subtracting the preweight of gauze from the final weight.
We have observed a statistically significant (P≤0.05) reduction of bleeding in PAI-1-treated group in comparison to saline and tPA-treated groups.
Based on these results we propose that VLHL PAI-1 can be used therapeutically in limiting the flow of blood from renal wounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shahrour, Khaled& Keck, Rick& Jankun, Jerzy. 2015. Application of Long-Acting VLHL PAI-1 during Sutureless Partial Nephrectomy in Mice Reduces Bleeding. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shahrour, Khaled…[et al.]. Application of Long-Acting VLHL PAI-1 during Sutureless Partial Nephrectomy in Mice Reduces Bleeding. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shahrour, Khaled& Keck, Rick& Jankun, Jerzy. Application of Long-Acting VLHL PAI-1 during Sutureless Partial Nephrectomy in Mice Reduces Bleeding. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055300
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر