Sialic Acid Expression in the Mosquito Aedes aegypti and Its Possible Role in Dengue Virus-Vector Interactions
المؤلفون المشاركون
Zenteno, Edgar
Cime-Castillo, Jorge
Delannoy, Philippe
Mendoza-Hernández, Guillermo
Monroy-Martínez, Verónica
Harduin-Lepers, Anne
Lanz-Mendoza, Humberto
Hernández-Hernández, Fidel de la Cruz
Cabello-Gutiérrez, Carlos
Ruiz-Ordaz, Blanca H.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-22
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Dengue fever (DF) is the most prevalent arthropod-borne viral disease which affects humans.
DF is caused by the four dengue virus (DENV) serotypes, which are transmitted to the host by the mosquito Aedes aegypti that has key roles in DENV infection, replication, and viral transmission (vector competence).
Mosquito saliva also plays an important role during DENV transmission.
In this study, we detected the presence of sialic acid (Sia) in Aedes aegypti tissues, which may have an important role during DENV-vector competence.
We also identified genome sequences encoding enzymes involved in Sia pathways.
The cDNA for Aedes aegypti CMP-Sia synthase (CSAS) was amplified, cloned, and functionally evaluated via the complementation of LEC29.Lec32 CSAS-deficient CHO cells.
AedesCSAS-transfected LEC29.Lec32 cells were able to express Sia moieties on the cell surface.
Sequences related to α-2,6-sialyltransferase were detected in the Aedes aegypti genome.
Likewise, we identified Sia-α-2,6-DENV interactions in different mosquito tissues.
In addition, we evaluated the possible role of sialylated molecules in a salivary gland extract during DENV internalization in mammalian cells.
The knowledge of early DENV-host interactions could facilitate a better understanding of viral tropism and pathogenesis to allow the development of new strategies for controlling DENV transmission.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cime-Castillo, Jorge& Delannoy, Philippe& Mendoza-Hernández, Guillermo& Monroy-Martínez, Verónica& Harduin-Lepers, Anne& Lanz-Mendoza, Humberto…[et al.]. 2015. Sialic Acid Expression in the Mosquito Aedes aegypti and Its Possible Role in Dengue Virus-Vector Interactions. BioMed Research International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1055721
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cime-Castillo, Jorge…[et al.]. Sialic Acid Expression in the Mosquito Aedes aegypti and Its Possible Role in Dengue Virus-Vector Interactions. BioMed Research International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1055721
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cime-Castillo, Jorge& Delannoy, Philippe& Mendoza-Hernández, Guillermo& Monroy-Martínez, Verónica& Harduin-Lepers, Anne& Lanz-Mendoza, Humberto…[et al.]. Sialic Acid Expression in the Mosquito Aedes aegypti and Its Possible Role in Dengue Virus-Vector Interactions. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1055721
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055721
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر