Metastatic Salivary Gland Tumors: A Single-Center Study Demonstrating the Feasibility and Potential Clinical Benefit of Molecular-Profiling-Guided Therapy
المؤلفون المشاركون
Popovtzer, Aron
Sarfaty, Michal
Limon, Dror
Marshack, Gideon
Perlow, Eli
Dvir, Addie
Soussan-Gutman, Lior
Stemmer, Salomon M.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We evaluated the use of molecular profiling (MP) for metastatic salivary gland adenoid cystic carcinoma (SACC), for which there is no standard treatment.
MP (Caris Molecular Intelligence) was performed on biopsy samples from all metastatic SACC patients attending a tertiary medical center between 2010 and 2013 n = 14 .
Treatment was selected according to the biomarkers identified.
Findings were compared with all similarly diagnosed patients treated in the same center between 1996 and 2009 n = 9 .
For each patient, MP identified 1–13 biomarkers associated with clinical benefit for specific therapies (most commonly low/negative TS, low ERCC1).
Eleven patients (79%) received MP-guided treatment (2 died prior to treatment initiation, 1 opted not to be treated), with complete response in 1, partial response (PR) in 3, and stable disease in 4.
In the historical controls, 2 patients (22%) were treated (1 had PR).
Median (range) progression-free survival in the first line after MP was 8.2 months (1.4–49.5+).
Median (range) overall survival from diagnosis of metastatic disease was 31.3 (1.4–71.1+) versus 14.0 (1.5–116) months in the historical controls.
In conclusion, MP expands treatment options and may improve clinical outcomes for metastatic SACC.
In orphan diseases where randomized trials cannot be performed, MP could become a standard clinical tool.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Popovtzer, Aron& Sarfaty, Michal& Limon, Dror& Marshack, Gideon& Perlow, Eli& Dvir, Addie…[et al.]. 2015. Metastatic Salivary Gland Tumors: A Single-Center Study Demonstrating the Feasibility and Potential Clinical Benefit of Molecular-Profiling-Guided Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056131
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Popovtzer, Aron…[et al.]. Metastatic Salivary Gland Tumors: A Single-Center Study Demonstrating the Feasibility and Potential Clinical Benefit of Molecular-Profiling-Guided Therapy. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056131
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Popovtzer, Aron& Sarfaty, Michal& Limon, Dror& Marshack, Gideon& Perlow, Eli& Dvir, Addie…[et al.]. Metastatic Salivary Gland Tumors: A Single-Center Study Demonstrating the Feasibility and Potential Clinical Benefit of Molecular-Profiling-Guided Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056131
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056131
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر