Ischemic Postconditioning and Subanesthetic S(+)-Ketamine Infusion: Effects on Renal Function and Histology in Rats
المؤلفون المشاركون
Domingues, Maria A. C.
Resende, Marco A. C. de
Pantoja, Alberto V.
Barcellos, Bruno M.
Reis, Eduardo P.
Consolo, Thays D.
Módolo, Renata P.
Assad, Alexandra R.
Cavalcanti, Ismar L.
Castiglia, Yara M. M.
Módolo, Norma S. P.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Ischemic postconditioning (IP) in renal Ischemia reperfusion injury (IRI) models improves renal function after IRI.
Ketamine affords significant benefits against IRI-induced acute kidney injury (AKI).
The present study investigated the effects of IP and IP associated with subanesthetic S(+)-ketamine in ischemia-reperfusion-induced AKI.
Methods.
Forty-one Wistar rats were randomized into four groups: CG (10), control; KG (10), S(+)-ketamine infusion; IPG (10), IP; and KIPG (11), S(+)-ketamine infusion + IP.
All rats underwent right nephrectomy.
IRI and IP were induced only in IPG and KIPG by left kidney arterial occlusion for 30 min followed by reperfusion for 24 h.
Complete reperfusion was preceded by three cycles of 2 min of reocclusion followed by 2 min of reperfusion.
Renal function was assessed by measuring serum neutrophil gelatinase-associated lipocalin (NGAL), creatinine, and blood urea nitrogen (BUN).
Tubular damage was evaluated by renal histology.
Results.
Creatinine and BUN were significantly increased.
Severe tubular injury was only observed in the groups with IRI (IPG and KIPG), whereas no injury was observed in CG or KG.
No significant differences were detected between IPG and KIPG.
Conclusions.
No synergic effect of the use of subanesthetic S(+)-ketamine and IP on AKI was observed in this rat model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Resende, Marco A. C. de& Pantoja, Alberto V.& Barcellos, Bruno M.& Reis, Eduardo P.& Consolo, Thays D.& Módolo, Renata P.…[et al.]. 2015. Ischemic Postconditioning and Subanesthetic S(+)-Ketamine Infusion: Effects on Renal Function and Histology in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057063
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Resende, Marco A. C. de…[et al.]. Ischemic Postconditioning and Subanesthetic S(+)-Ketamine Infusion: Effects on Renal Function and Histology in Rats. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057063
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Resende, Marco A. C. de& Pantoja, Alberto V.& Barcellos, Bruno M.& Reis, Eduardo P.& Consolo, Thays D.& Módolo, Renata P.…[et al.]. Ischemic Postconditioning and Subanesthetic S(+)-Ketamine Infusion: Effects on Renal Function and Histology in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057063
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057063
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر