Fishing for Nature’s Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products
المؤلفون المشاركون
Tabassum, Nadia
Tai, Hongmei
Jung, Da-Woon
Williams, Darren R.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-23
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Diabetes mellitus affects millions of people worldwide and significantly impacts their quality of life.
Moreover, life threatening diseases, such as myocardial infarction, blindness, and renal disorders, increase the morbidity rate associated with diabetes.
Various natural products from medicinal plants have shown potential as antidiabetes agents in cell-based screening systems.
However, many of these potential “hits” fail in mammalian tests, due to issues such as poor pharmacokinetics and/or toxic side effects.
To address this problem, the zebrafish (Danio rerio) model has been developed as a “bridge” to provide an experimentally convenient animal-based screening system to identify drug candidates that are active in vivo.
In this review, we discuss the application of zebrafish to drug screening technologies for diabetes research.
Specifically, the discovery of natural product-based antidiabetes compounds using zebrafish will be described.
For example, it has recently been demonstrated that antidiabetic natural compounds can be identified in zebrafish using activity guided fractionation of crude plant extracts.
Moreover, the development of fluorescent-tagged glucose bioprobes has allowed the screening of natural product-based modulators of glucose homeostasis in zebrafish.
We hope that the discussion of these advances will illustrate the value and simplicity of establishing zebrafish-based assays for antidiabetic compounds in natural products-based laboratories.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tabassum, Nadia& Tai, Hongmei& Jung, Da-Woon& Williams, Darren R.. 2015. Fishing for Nature’s Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1061320
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tabassum, Nadia…[et al.]. Fishing for Nature’s Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1061320
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tabassum, Nadia& Tai, Hongmei& Jung, Da-Woon& Williams, Darren R.. Fishing for Nature’s Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1061320
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061320
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر