Effects of a Proprietary Standardized Orthosiphon stamineus Ethanolic Leaf Extract on Enhancing Memory in Sprague Dawley Rats Possibly via Blockade of Adenosine A 2A Receptors
المؤلفون المشاركون
George, Annie A.
Chinnappan, Sasikala
Choudhary, Yogendra
Choudhary, Vandana Kotak
Bommu, Praveen
Wong, Hoi Jin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of the study was to explore a propriety standardized ethanolic extract from leaves of Orthosiphon stamineus Benth in improving impairments in short-term social memory in vivo, possibly via blockade of adenosine A2A receptors (A2AR).
The ethanolic extract of O.
stamineus leaves showed significant in vitro binding activity of A2AR with 74% inhibition at 150 μ g/ml and significant A2AR antagonist activity with 98% inhibition at 300 μ g/mL.
A significant adenosine A1 receptor (A1R) antagonist activity with 100 % inhibition was observed at 300 μ g/mL.
Its effect on learning and memory was assessed via social recognition task using Sprague Dawley rats whereby the ethanolic extract of O.
stamineus showed significant ( p < 0.001 ) change in recognition index (RI) at 300 mg/kg and 600 mg/kg p.o and 120 mg/kg i.p., respectively, compared to the vehicle control.
In comparison, the ethanolic extract of Polygonum minus aerial parts showed small change in inflexion; however, it remained insignificant in RI at 200 mg/kg p.o.
Our findings suggest that the ethanolic extract of O.
stamineus leaves improves memory by reversing age-related deficits in short-term social memory and the possible involvement of adenosine A1 and adenosine A2A as a target bioactivity site in the restoration of memory.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
George, Annie A.& Chinnappan, Sasikala& Choudhary, Yogendra& Choudhary, Vandana Kotak& Bommu, Praveen& Wong, Hoi Jin. 2015. Effects of a Proprietary Standardized Orthosiphon stamineus Ethanolic Leaf Extract on Enhancing Memory in Sprague Dawley Rats Possibly via Blockade of Adenosine A 2A Receptors. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061423
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
George, Annie A.…[et al.]. Effects of a Proprietary Standardized Orthosiphon stamineus Ethanolic Leaf Extract on Enhancing Memory in Sprague Dawley Rats Possibly via Blockade of Adenosine A 2A Receptors. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061423
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
George, Annie A.& Chinnappan, Sasikala& Choudhary, Yogendra& Choudhary, Vandana Kotak& Bommu, Praveen& Wong, Hoi Jin. Effects of a Proprietary Standardized Orthosiphon stamineus Ethanolic Leaf Extract on Enhancing Memory in Sprague Dawley Rats Possibly via Blockade of Adenosine A 2A Receptors. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061423
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1061423
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر