PMC-12, a Prescription of Traditional Korean Medicine, Improves Amyloid β -Induced Cognitive Deficits through Modulation of Neuroinflammation
المؤلفون المشاركون
Choi, Byung Tae
Park, Min Young
Jung, Yeon Suk
Park, Jung Hwa
Choi, Young Whan
Lee, Jaewon
Kim, Cheol Min
Baek, Jin Ung
Shin, Hwa Kyoung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
PMC-12 is a prescription used in traditional Korean medicine that consists of a mixture of four herbal medicines, Polygonum multiflorum, Rehmannia glutinosa, Polygala tenuifolia, and Acorus gramineus, which have been reported to have various pharmacological effects on age-related neurological diseases.
In the present study, we investigated whether PMC-12 improves cognitive deficits associated with decreased neuroinflammation in an amyloid-β-(Aβ-) induced mouse model and exerts the antineuroinflammatory effects in lipopolysaccharide-(LPS-) stimulated murine BV2 microglia.
Intracerebroventricular injection of A β 25 - 35 in mice resulted in impairment in learning and spatial memory, whereas this was reversed by oral administration of PMC-12 (100 and 500 mg/kg/day) in dose-dependent manners.
Moreover, PMC-12 reduced the increase of Aβ expression and activation of microglia and astrocytes in the A β 25 - 35 -injected brain.
Furthermore, quantitative PCR data showed that inflammatory mediators were significantly decreased by administration of PMC-12 in Aβ-injected brains.
Consistent with the in vivo data, PMC-12 significantly reduced the inflammatory mediators in LPS-stimulated BV2 cells without cell toxicity.
Moreover, PMC-12 exhibited anti-inflammatory properties via downregulation of ERK, JNK, and p38 MAPK pathways.
These findings suggest that the protective effects of PMC-12 may be mediated by its antineuroinflammatory activities, resulting in the attenuation of memory impairment; accordingly, PMC-12 may be useful in the prevention and treatment of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Min Young& Jung, Yeon Suk& Park, Jung Hwa& Choi, Young Whan& Lee, Jaewon& Kim, Cheol Min…[et al.]. 2015. PMC-12, a Prescription of Traditional Korean Medicine, Improves Amyloid β -Induced Cognitive Deficits through Modulation of Neuroinflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063582
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Min Young…[et al.]. PMC-12, a Prescription of Traditional Korean Medicine, Improves Amyloid β -Induced Cognitive Deficits through Modulation of Neuroinflammation. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063582
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Min Young& Jung, Yeon Suk& Park, Jung Hwa& Choi, Young Whan& Lee, Jaewon& Kim, Cheol Min…[et al.]. PMC-12, a Prescription of Traditional Korean Medicine, Improves Amyloid β -Induced Cognitive Deficits through Modulation of Neuroinflammation. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063582
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063582
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر