Involvement of Cholinergic and Opioid System in γ-Terpinene-Mediated Antinociception
المؤلفون المشاركون
Passos, Flávia Franceli de Brito
Lopes, Everton Moraes
de Araújo, Jonas Moura
Veras, Leiz Maria C.
Almeida, Fernanda Regina de Castro
de Sousa, Damião Pergentino
Leite, José Roberto de S. A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The literature shows that the monoterpenes are great candidates for the development of new drugs for the treatment of various pathological processes, including painful conditions.
The gamma terpinene (γ-TPN) is a monoterpene present in plant species that have multiple pharmacological properties and has structural similarity to antinociceptive monoterpenes, such as limonene and alpha-phellandrene.
The γ-TPN molecular mass was evaluated by mass spectrometry and showed a pseudomolecular ion with m / z 137.0 Da.
The animals did not present any signs of acute toxicity at 2 g/kg, p.o.
γ-TPN (1.562 to 50 mg/kg, p.o.) showed an antinociceptive effect in the formalin, capsaicin, and glutamate tests.
γ-TPN has antinociceptive action when administered by others routes in glutamate test.
To eliminate a possible sedative effect of γ-TPN, the open field and rota-rod test were conducted and the γ-TPN did not show muscle relaxant activity or central depressant effect.
To investigate the mechanisms of action, the animals were pretreated with naloxone, glibenclamide, atropine, mecamylamine, or L-arginine in the glutamate test.
γ-TPN antinociception was inhibited in the presence of naloxone, glibenclamide, atropine, and mecamylamine.
The results suggest that the γ-TPN (p.o.) produced antinociceptive effect in models of chemical nociception through the cholinergic and opioid systems involvement.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Passos, Flávia Franceli de Brito& Lopes, Everton Moraes& de Araújo, Jonas Moura& de Sousa, Damião Pergentino& Veras, Leiz Maria C.& Leite, José Roberto de S. A.…[et al.]. 2015. Involvement of Cholinergic and Opioid System in γ-Terpinene-Mediated Antinociception. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Passos, Flávia Franceli de Brito…[et al.]. Involvement of Cholinergic and Opioid System in γ-Terpinene-Mediated Antinociception. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Passos, Flávia Franceli de Brito& Lopes, Everton Moraes& de Araújo, Jonas Moura& de Sousa, Damião Pergentino& Veras, Leiz Maria C.& Leite, José Roberto de S. A.…[et al.]. Involvement of Cholinergic and Opioid System in γ-Terpinene-Mediated Antinociception. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر